Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. (Q34330600)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23454242%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer (English)

1 reference

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Parthasarathy Seshacharyulu

24 February 2020

author

1

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24 February 2020

author name string

Poomy Pandey

2

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24 February 2020

Kaustubh Datta

3

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24 February 2020

Surinder K Batra

4

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24 February 2020

language of work or name

English

0 references

publication date

20 February 2013

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24 February 2020

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24 February 2020

volume

335

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24 February 2020

page(s)

9-18

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24 February 2020

issue

1

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CIP2A is a target of bortezomib in human triple negative breast cancer cells

24 February 2020

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A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A

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Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk

6 July 2018

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6 July 2018

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Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development

6 July 2018

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

6 July 2018

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CIP2A inhibits PP2A in human malignancies

6 July 2018

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Structural Basis of PP2A Inhibition by Small t Antigen

6 July 2018

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

6 July 2018

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Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.

6 July 2018

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Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

6 July 2018

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Identification of proteins interacting with the catalytic subunit of PP2A by proteomics

6 July 2018

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

6 July 2018

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

6 July 2018

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6 July 2018

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Shugoshin collaborates with protein phosphatase 2A to protect cohesin

6 July 2018

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

6 July 2018

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The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity

6 July 2018

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Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution

6 July 2018

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Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

6 July 2018

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Protein phosphatase-2A regulates endothelial cell motility and both the phosphorylation and the stability of focal adhesion complexes

6 July 2018

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Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation

6 July 2018

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B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster

6 July 2018

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Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest

6 July 2018

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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

6 July 2018

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Role of serine/threonine protein phosphatase 2A in cancer

6 July 2018

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Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells

6 July 2018

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Process formation of podocytes: morphogenetic activity of microtubules and regulation by protein serine/threonine phosphatase PP2A.

6 July 2018

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

6 July 2018

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6 July 2018

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

6 July 2018

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Type 2A protein phosphatase, the complex regulator of numerous signaling pathways

6 July 2018

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Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene

6 July 2018

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Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A,B'.

6 July 2018

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6 July 2018

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WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

6 July 2018

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A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation

6 July 2018

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6 July 2018

The Hallmarks of Cancer

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PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells

6 July 2018

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Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A

6 July 2018

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Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells

6 July 2018

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Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.

6 July 2018

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Regulation of protein kinase cascades by protein phosphatase 2A.

6 July 2018

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Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

6 July 2018

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Rapid dephosphorylation of p107 following UV irradiation.

6 July 2018

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Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor

6 July 2018

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Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha

6 July 2018

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Alterations of the PPP2R1B gene in human lung and colon cancer

6 July 2018

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Autoregulation of protein phosphatase type 2A expression

6 July 2018

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Alpha 4 associates with protein phosphatases 2A, 4, and 6

6 July 2018

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Novel protein serine/threonine phosphatases: variety is the spice of life

6 July 2018

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Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells.

6 July 2018

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Molecular mechanisms of the protein serine/threonine phosphatases

6 July 2018

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The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

6 July 2018

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Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle

6 July 2018

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High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms

6 July 2018

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Molecular cloning of a 74-kDa regulatory subunit (B" or delta) of human protein phosphatase 2A

6 July 2018

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Flicking the switches: phosphorylation of serine/threonine protein phosphatases

6 July 2018

1 reference

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Protein serine/threonine phosphatases as binding proteins for okadaic acid

6 July 2018

1 reference

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Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

6 July 2018

2 references

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6 July 2018

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Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

27 October 2018

1 reference

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Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A

6 July 2018

1 reference

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Comparison of heterotrimeric protein phosphatase 2A containing different B subunits.

6 July 2018

1 reference

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Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.

6 July 2018

1 reference

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Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.

6 July 2018

1 reference

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Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Constant expression and activity of protein phosphatase 2A in synchronized cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Protein phosphatase-2A restricts migration of Lewis lung carcinoma cells by modulating the phosphorylation of focal adhesion proteins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3665613

Autophosphorylation-activated protein kinase inactivates the protein tyrosine phosphatase activity of protein phosphatase 2A

27 October 2018

1 reference

12 December 2020

Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

1 reference

12 December 2020

Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes

1 reference

12 December 2020

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers

1 reference

12 December 2020

Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A

1 reference

12 December 2020

Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity

1 reference

12 December 2020

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

1 reference

12 December 2020

The protein phosphatases involved in cellular regulation. 2. Purification, subunit structure and properties of protein phosphatases-2A0, 2A1, and 2A2 from rabbit skeletal muscle

1 reference

12 December 2020

Protein phosphatase 2A--a 'ménage à trois'

1 reference

12 December 2020

Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4

1 reference

12 December 2020

Effects of regulatory subunits on the kinetics of protein phosphatase 2A

1 reference

12 December 2020

Protein phosphatase-2A associates with the cytoskeleton to maintain cell spreading and reduced motility of nonmetastatic Lewis lung carcinoma cells: the loss of this regulatory control in metastatic cells

1 reference

12 December 2020

Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis

1 reference

12 December 2020

10.1016/J.CANLET.2013.02.036

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23454242%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23454242%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference