Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion (Q34388870)

1 August 2017

title

Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion (English)

1 reference

1 August 2017

Avraam El Hamidieh

1

1 reference

1 August 2017

Nicholas Grammatikakis

series ordinal

2

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1 August 2017

Evangelia Patsavoudi

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

17 August 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

8

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1 August 2017

page(s)

e42722

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

17 August 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

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Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion

6 July 2018

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Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

6 July 2018

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Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning

6 July 2018

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Targeting the oncogene and kinome chaperone CDC37.

6 July 2018

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Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

6 July 2018

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A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.

6 July 2018

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Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis

6 July 2018

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Monoclonal antibody 4C5 immunostains human melanomas and inhibits melanoma cell invasion and metastasis.

6 July 2018

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The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.

6 July 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

6 July 2018

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Heat shock proteins in cancer: chaperones of tumorigenesis

6 July 2018

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Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition

6 July 2018

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HSP90 and the chaperoning of cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

6 July 2018

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Extracellular roles for the molecular chaperone, hsp90.

6 July 2018

1 reference

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Involvement of cell surface HSP90 in cell migration reveals a novel role in the developing nervous system

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Heat-shock protein 90, a chaperone for folding and regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Hsp90 inhibitors as novel cancer chemotherapeutic agents

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Analysis of mammalian Cdc37, a protein kinase targeting subunit of heat shock protein 90.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Cdc37 is a molecular chaperone with specific functions in signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Purification and Characterization of Neuron-Specific Surface Antigen Defined by Monoclonal Antibody BM88

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Changes in apoptosis-related pathways in acute myelocytic leukemia

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Identification of a novel neuron-specific surface antigen in the developing nervous system, by monoclonal antibody 4C5.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422348

Cyclin D1 overexpression is not a specific grouping marker, but may collaborate with CDC37 in myeloma cells

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22912728

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0042722

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference