Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging (Q34415909)

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13 February 2020

title

Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging (English)

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12

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Derya R Shimshek

10

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13 February 2020

Richard Faull

11

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author name string

David Marcellin

1

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13 February 2020

Dorothee Abramowski

2

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13 February 2020

Douglas Young

3

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13 February 2020

Jens Richter

4

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Andreas Weiss

5

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Audrey Marcel

6

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Julia Maassen

7

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Muriel Kauffmann

8

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13 February 2020

Miriam Bibel

9

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13 February 2020

Rainer R Kuhn

13

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P Herman Van der Putten

14

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Peter Schmid

15

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Gregor P Lotz

16

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13 February 2020

language of work or name

English

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publication date

12 September 2012

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13 February 2020

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13 February 2020

volume

7

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13 February 2020

issue

9

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13 February 2020

page(s)

e44457

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Creative Commons Attribution 4.0 International

13 February 2020

copyright license

start time

12 September 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

6 July 2018

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Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

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Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

6 July 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

27 October 2018

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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

27 October 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

27 October 2018

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

27 October 2018

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Formation of polyglutamine inclusions in non-CNS tissue

27 October 2018

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

27 October 2018

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27 October 2018

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Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells

27 October 2018

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10.1371/JOURNAL.PONE.0044457

9 December 2018

Identifiers

DOI

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13 February 2020

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24 November 2022

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13 February 2020

PubMed publication ID

22984513

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