Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy (Q44962020)

7 December 2017

title

Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy (English)

1 reference

7 December 2017

Kathleen A Burke

1

1 reference

7 December 2017

Jordan Godbey

series ordinal

2

1 reference

7 December 2017

Justin Legleiter

series ordinal

3

1 reference

7 December 2017

language of work or name

1 reference

25 December 2010

1 reference

7 December 2017

1 reference

7 December 2017

volume

53

1 reference

7 December 2017

issue

3

1 reference

7 December 2017

page(s)

275-284

1 reference

describes a project that uses

7 December 2017

atomic force microscopy

1 reference

based on heuristic

inferred from title

cites work

Familial conformational diseases and dementias

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Cell death: protein misfolding and neurodegenerative diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

A specific amyloid-beta protein assembly in the brain impairs memory

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Glutamine repeats and neurodegeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

CAG repeat number governs the development rate of pathology in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Spatial positions of homopolymeric repeats in the human proteome and their effect on cellular toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Normal aging modulates the neurotoxicity of mutant huntingtin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

A cellular model that recapitulates major pathogenic steps of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Morphological Development of β(1-40) Amyloid Fibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

In-situ atomic force microscopy study of β-amyloid fibrillization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: new insights into mechanism of beta-sheet formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Stepwise dynamics of epitaxially growing single amyloid fibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

7 January 2021

Atomic force microscope

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Combined AFM and confocal fluorescence microscope for applications in bio-nanotechnology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Abeta42-peptide assembly on lipid bilayers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Collagen VI protects neurons against Abeta toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Viscoelasticity of living cells allows high resolution imaging by tapping mode atomic force microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Temperature-dependent imaging of living cells by AFM.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Improved localization of cellular membrane receptors using combined fluorescence microscopy and simultaneous topography and recognition imaging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Micromechanical architecture of the endothelial cell cortex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Algorithms for Scanned Probe Microscope Image Simulation, Surface Reconstruction, and Tip Estimation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Solubilization and disaggregation of polyglutamine peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Modulation of polyglutamine conformations and dimer formation by the N-terminus of huntingtin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Hydrodynamics and protein hydration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Surface-catalyzed amyloid fibril formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Model discrimination and mechanistic interpretation of kinetic data in protein aggregation studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polyglutamines placed into context

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Expansion of amino acid homo-sequences in proteins: insights into the role of amino acid homo-polymers and of the protein context in aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Oligoproline effects on polyglutamine conformation and aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Flanking polyproline sequences inhibit beta-sheet structure in polyglutamine segments by inducing PPII-like helix structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

A network of protein interactions determines polyglutamine toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Flanking sequences profoundly alter polyglutamine toxicity in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Neurotoxic protein oligomerisation associated with polyglutamine diseases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin contains a highly conserved nuclear export signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Huntingtin associates with acidic phospholipids at the plasma membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polyglutamine expansion in huntingtin alters its interaction with phospholipids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Modulation of neurodegeneration by molecular chaperones

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and alpha-synuclein aggregates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Single chain Fv antibodies against the 25-35 Abeta fragment inhibit aggregation and toxicity of Abeta42.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Inhibition of insulin amyloid formation by small stress molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Polymorphism in the intermediates and products of amyloid assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

Hsp70 and Hsp40 Functionally Interact with Soluble Mutant Huntingtin Oligomers in a Classic ATP-dependent Reaction Cycle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2010.12.028

10.1016/J.YMETH.2010.12.028

7 January 2021

Identifiers

DOI

1 reference

7 December 2017

1 reference