Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease (Q34417946)

2 August 2017

1 reference

title

Amyloid-beta: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease (English)

1 reference

2 August 2017

0 references

Kontush A

1

1 reference

2 August 2017

1 November 2001

1 reference

Free Radical Biology and Medicine

2 August 2017

1 reference

2 August 2017

31

1 reference

2 August 2017

9

1 reference

2 August 2017

1120-1131

1 reference

Amyloid, the presenilins and Alzheimer's disease

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidative stress in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Mitochondrial involvement in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidative damage and mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Metals and neuroscience.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Copper catalyzed oxidation of ascorbate (vitamin C). Inhibitory effect of catalase, superoxide dismutase, serum proteins (ceruloplasmin, albumin, apotransferrin) and amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Tl2+ and Ag2+ metal-ion-induced oxidation of methionine in aqueous solution. A pulse radiolysis study

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidation of high density lipoproteins. II. Evidence for direct reduction of lipid hydroperoxides by methionine residues of apolipoproteins AI and AII

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Mitochondrial free radical generation, oxidative stress, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid-beta peptides are cytotoxic to oligodendrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidative stress hypothesis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The toxicity in vitro of beta-amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Promotion of transition metal-induced reactive oxygen species formation by beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The role of iron in beta amyloid toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Redox-active iron mediates amyloid-beta toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The effect of albumin on copper-induced LDL oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Alpha-tocopherol as a reductant for Cu(II) in human lipoproteins. Triggering role in the initiation of lipoprotein oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The effect of ascorbate and ubiquinone supplementation on plasma and CSF total antioxidant capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Increased lipoprotein oxidation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Soluble amyloid beta-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

RNA Oxidation in Alzheimer and Parkinson Diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Platelets are the primary source of amyloid beta-peptide in human blood

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Alzheimer's soluble amyloid beta protein is secreted by HepG2 cells as an apolipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Peptides in membranes: tipping the balance of membrane stability

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Beta-amyloid protein promotes neuritic branching in hippocampal cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Processing of Alzheimer's amyloid precursor protein during H2O2-induced apoptosis in human neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

A beta 42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Does human betaA4 exert a protective function against oxidative stress in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Differential alterations in antioxidant capacity in cells from Alzheimer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Differential expression of cytochrome oxidase (COX) genes in different regions of monkey brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Normal and pathological aging--findings of positron-emission-tomography.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Microglial in neurodegenerative disorders: emphasis on Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The oxidation of lipoproteins by monocytes-macrophages. Biochemical and biological mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Arson. Tracking the culprit in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Apolipoprotein E4: an allele associated with many diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Intramuscular desferrioxamine in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Statins and the risk of dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

The role of cholesterol in the biosynthesis of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2801%2900688-8

7 January 2021

10.1016/S0891-5849(01)00688-8

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11677045