Review: tubulin function, action of antitubulin drugs, and new drug development (Q34425460)

2 August 2017

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title

Review: tubulin function, action of antitubulin drugs, and new drug development (English)

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2 August 2017

Federico Pellegrini

1

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PubMed ID

15948296

2 August 2017

Daniel R Budman

series ordinal

2

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2 August 2017

1 January 2005

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2 August 2017

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2 August 2017

23

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2 August 2017

3

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2 August 2017

264-273

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Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells

2 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Diversity screening versus focussed screening in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Microtubules and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Kinesin carries the signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

A plus-end raft to control microtubule dynamics and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The spindle: a dynamic assembly of microtubules and motors

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Tubulin and microtubule structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Complex regulation and functional versatility of mammalian alpha- and beta-tubulin isotypes during the differentiation of testis and muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Posttranslational modification and microtubule stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Epsilon-tubulin is required for centriole duplication and microtubule organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Molecular effects of paclitaxel: myths and reality (a critical review).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The three-dimensional structure of tubulin protofilaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Physiochemical aspects of tubulin-interacting antimitotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Structural insights into microtubule function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Nucleotide binding and phosphorylation in microtubule assembly in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Determination of the size and chemical nature of the stabilizing "cap" at microtubule ends using modulators of polymerization dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (alpha,beta)methylenediphosphonate

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Dynamic instability of microtubule growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Microtubule dynamic instability and GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Microtubule treadmilling: what goes around comes around

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Accessory protein regulation of microtubule dynamics throughout the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Microtubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The molecular basis and potential role of survivin in cancer diagnosis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The mitotic spindle: a self-made machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Enhancement of radiation therapy by the novel vascular targeting agent ZD6126.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Preclinical antitumor activity of two novel taxanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Phase I clinical and pharmacokinetic studies of the taxoid derivative RPR 109881A administered as a 1-hour or a 3-hour infusion in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Phase I dose-finding study of a new taxane, RPR 109881A, administered as a one-hour intravenous infusion days 1 and 8 to patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Promising new developments in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Anticancer therapy with novel tubulin-interacting drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Direct photoaffinity labeling of tubulin with colchicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Localization of the vinblastine-binding site on beta-tubulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Epothilones: a novel class of non-taxane microtubule-stabilizing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Total syntheses of epothilones B and D

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Paclitaxel-induced cell death: where the cell cycle and apoptosis come together

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Taxanes: a new class of antitumor agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Characterization of nuclear betaII-tubulin in tumor cells: a possible novel target for taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Taxol suppresses dynamics of individual microtubules in living human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Novel molecules that interact with microtubules and have functional activity similar to Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Stabilization of microtubule dynamics by estramustine by binding to a novel site in tubulin: a possible mechanistic basis for its antitumor action

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Mechanisms of action and resistance to tubulin-binding agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Molecular mechanisms of resistance to taxanes and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Kinesin molecular motors: transport pathways, receptors, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Inhibitors of kinesin activity from structure-based computer screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Translating basic cancer research into new cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

Characterization of the Taxol Binding Site on the Microtubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-200055970

21 January 2018

Identifiers

DOI

10.1081/CNV-200055970

1 reference

release_nr57xdoxazek5ild6cndbkomlq

2 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nr57xdoxazek5ild6cndbkomlq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

15948296

1 reference

PubMed ID

15948296