A gp130-Src-YAP module links inflammation to epithelial regeneration (Q34465259)

2 August 2017

title

A gp130-Src-YAP module links inflammation to epithelial regeneration (English)

1 reference

2 August 2017

0 references

Rous sarcoma oncogene

1 reference

GOA release 2020-03-11

Yes-associated protein 1

1 reference

Interleukin 6 signal transducer

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

16

Jessica Zucman-Rossi

0 references

Michael Karin

18

Michael Karin

1 reference

2 August 2017

John T Chang

10

0 references

Li-Wha Wu

Li-Wha Wu

2

0 references

Gary Hardiman

Gary Hardiman

12

0 references

William Jeffery Sandborn

11

William J Sandborn

1 reference

2 August 2017

Koji Taniguchi

1

1 reference

2 August 2017

Sergei I Grivennikov

3

1 reference

2 August 2017

Petrus R de Jong

4

1 reference

2 August 2017

Ian Lian

5

1 reference

2 August 2017

Fa-Xing Yu

6

1 reference

2 August 2017

Kepeng Wang

7

1 reference

2 August 2017

Samuel B Ho

8

1 reference

2 August 2017

Brigid S Boland

9

1 reference

2 August 2017

Eyal Raz

13

1 reference

2 August 2017

Yoshihiko Maehara

14

1 reference

2 August 2017

Akihiko Yoshimura

15

1 reference

2 August 2017

Kun-Liang Guan

17

1 reference

2 August 2017

language of work or name

English

0 references

publication date

25 February 2015

1 reference

2 August 2017

1 reference

2 August 2017

volume

519

1 reference

2 August 2017

issue

7541

1 reference

2 August 2017

page(s)

57-62

1 reference

describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4447318/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

c-Src drives intestinal regeneration and transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The role of Src in colon cancer and its therapeutic implications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

New targets for mucosal healing and therapy in inflammatory bowel diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

A degenerative retinal process in HIV-associated non-infectious retinopathy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The Hippo pathway: regulators and regulations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Plasticity and cross-talk of interleukin 6-type cytokines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Organ repair and regeneration: an overview.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Therapeutic targeting of the interleukin-6 receptor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Inflammation meets cancer, with NF-κB as the matchmaker

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

IL-6: from its discovery to clinical applications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Immunity, Inflammation, and Cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Origin and physiological roles of inflammation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

YAP1 increases organ size and expands undifferentiated progenitor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Identification of stem cells in small intestine and colon by marker gene Lgr5

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

SOCS proteins, cytokine signalling and immune regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Notch signalling: a simple pathway becomes complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Essential role of STAT3 for embryonic stem cell pluripotency

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447318

Requirement of Notch activation during regeneration of the intestinal epithelia

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

Notch signals control the fate of immature progenitor cells in the intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14228

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25731159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25731159

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE14228

1 reference

2 August 2017

1 reference

2 August 2017

1 reference