Prospects for anti-ras drugs (Q34534438)

2 August 2017

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title

Prospects for anti-ras drugs (English)

1 reference

2 August 2017

Mohammad Reza Ahmadian

series ordinal

1

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PubMed ID

11849206

2 August 2017

language of work or name

English

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publication date

1 March 2002

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British Journal of Haematology

2 August 2017

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2 August 2017

116

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2 August 2017

3

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2 August 2017

511-518

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

2 August 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Guanosine triphosphatase stimulation of oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

ras oncogenes: their role in neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

In vitro inhibition of Ras-Raf association by short peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

RAS and leukemia: from basic mechanisms to gene-directed therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The GTPase superfamily: a conserved switch for diverse cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Increasing complexity of Ras signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Protein prenyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

GEFs: structural basis for their activation of small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyl transferase inhibitors: current developments and future perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

RNA-triggered gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Selective GRB2 SH2 inhibitors as anti-Ras therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The prevention of colorectal cancer by aspirin use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Dislodgment and accelerated degradation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

21 January 2018

Ras and its effectors

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Sulindac sulfide inhibits Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Inhibition of RAS-targeted prenylation: protein farnesyl transferase inhibitors revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Ras effectors and their role in mitogenesis and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

RAS inhibitors: potential for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Concepts in Ras-directed therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Substrate assisted catalysis -- application to G proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Nanoparticulate systems for the delivery of antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Antisense oligonucleotides: promise and reality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Ras farnesyltransferase: a new therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Interactions between Ras proteins and their effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

New insights into the interaction of Ras with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Inhibition of human tumor cell growth in vivo by an orally bioavailable inhibitor of human farnesyltransferase, BIM-46228.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The Ras branch of small GTPases: Ras family members don't fall far from the tree

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The role of ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

GTPase-activating proteins: helping hands to complement an active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Understanding Ras: 'it ain't over 'til it's over'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

Ras and Rap1: two highly related small GTPases with distinct function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0007-1048.2001.03314.X

10.1046/J.0007-1048.2001.03314.X

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11849206