Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch (Q34552749)

3 August 2017

title

Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch (English)

1 reference

3 August 2017

0 references

1 reference

Robert F Gahl

1

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3 August 2017

Yi He

series ordinal

2

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3 August 2017

Shiqin Yu

series ordinal

3

1 reference

3 August 2017

Nico Tjandra

series ordinal

4

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3 August 2017

language of work or name

English

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publication date

14 October 2014

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Journal of Biological Chemistry

3 August 2017

published in

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3 August 2017

volume

289

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3 August 2017

issue

47

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3 August 2017

page(s)

32871-32882

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describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4239635/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

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7 July 2018

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Defining the role of the Bcl-2 family proteins in Huntington's disease

7 July 2018

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Single color FRET based measurements of conformational changes of proteins resulting from translocation inside cells

7 July 2018

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Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming

7 July 2018

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PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

7 July 2018

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Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?

7 July 2018

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

7 July 2018

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BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

7 July 2018

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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

7 July 2018

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The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

7 July 2018

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Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

7 July 2018

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ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation

7 July 2018

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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

7 July 2018

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The BCL-2 protein family: opposing activities that mediate cell death

7 July 2018

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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

7 July 2018

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TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

7 July 2018

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

7 July 2018

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Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

7 July 2018

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The pathophysiology of mitochondrial cell death

7 July 2018

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

7 July 2018

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Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol.

7 July 2018

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7 July 2018

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The Bcl2 family: regulators of the cellular life-or-death switch

7 July 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

7 July 2018

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Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy

7 July 2018

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Movement of Bax from the cytosol to mitochondria during apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4239635

Beta-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

7 July 2018

1 reference

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The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.593897

Molecular details of Bax activation, oligomerization, and membrane insertion.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.593897

Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.593897

21 January 2018

Identifiers

DOI

10.1074/JBC.M114.593897

1 reference

3 August 2017

1 reference

3 August 2017

1 reference