Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases (Q34572847)

3 August 2017

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title

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases (English)

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3 August 2017

Mary C Sugden

1

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3 August 2017

Mark J Holness

series ordinal

2

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3 August 2017

publication date

1 July 2006

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Archives of Physiology and Biochemistry

3 August 2017

published in

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3 August 2017

volume

112

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3 August 2017

issue

3

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3 August 2017

page(s)

139-149

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Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells

3 August 2017

cites work

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Activation of glucose transport during simulated ischemia in H9c2 cardiac myoblasts is mediated by protein kinase C isoforms

21 January 2018

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Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression

21 January 2018

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Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

21 January 2018

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Marked differences between two isoforms of human pyruvate dehydrogenase kinase

21 January 2018

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Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP

21 January 2018

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Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP

21 January 2018

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Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

21 January 2018

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Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver

21 January 2018

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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

21 January 2018

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2-Oxo acid dehydrogenase complexes in redox regulation

21 January 2018

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Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

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"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

21 January 2018

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Potent inactivation of representative members of each PKC isozyme subfamily and PKD via S-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine

21 January 2018

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Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation

21 January 2018

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Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase

21 January 2018

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Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Diversity of the pyruvate dehydrogenase kinase gene family in humans

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex

21 January 2018

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Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

21 January 2018

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https://api.crossref.org/works/10.1080%2F13813450600935263

Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Mutagenesis studies of the phosphorylation sites of recombinant human pyruvate dehydrogenase. Site-specific regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Mechanisms responsible for regulation of pyruvate dehydrogenase kinase 4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

α-Keto acid dehydrogenase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Longer-term regulation of pyruvate dehydrogenase kinase in cultured rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

RXR activators molecular signalling: involvement of a PPAR alpha-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Putative metabolic effects of the liver X receptor (LXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Effects of re-feeding after prolonged starvation on pyruvate dehydrogenase activities in heart, diaphragm and selected skeletal muscles of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Fibre-type specific modification of the activity and regulation of skeletal muscle pyruvate dehydrogenase kinase (PDK) by prolonged starvation and refeeding is associated with targeted regulation of PDK isoenzyme 4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Role of peroxisome proliferator-activated receptor-alpha in the mechanism underlying changes in renal pyruvate dehydrogenase kinase isoform 4 protein expression in starvation and after refeeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Function of phosphorylation sites on pyruvate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

LXR, a nuclear receptor that defines a distinct retinoid response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F13813450600935263

10.1080/13813450600935263

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

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