The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence (Q44133854)

30 November 2017

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence (English)

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30 November 2017

1

1 reference

30 November 2017

M Claire Bartlett

2

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PubMed ID

12226074

30 November 2017

David M Clarke

series ordinal

3

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PubMed ID

12226074

30 November 2017

language of work or name

English

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publication date

10 September 2002

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Journal of Biological Chemistry

30 November 2017

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30 November 2017

277

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30 November 2017

44

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30 November 2017

41303-41306

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ABC Transporters: From Microorganisms to Man

30 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.C200484200

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200484200

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.C200484200

The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

The anatomy and taxonomy of protein structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

P-glycoprotein. Associations between domains and between domains and molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Crystal structure of the ATP-binding subunit of an ABC transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C200484200

21 January 2018

Identifiers

DOI

10.1074/JBC.C200484200

1 reference

30 November 2017

1 reference

PubMed ID

12226074