RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage (Q34761198)

4 August 2017

RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage (English)

1 reference

4 August 2017

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Ryo Sakasai

1

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PubMed ID

18337245

4 August 2017

Randal Tibbetts

series ordinal

2

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PubMed ID

18337245

4 August 2017

language of work or name

English

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publication date

12 March 2008

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Journal of Biological Chemistry

4 August 2017

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4 August 2017

283

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4 August 2017

20

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4 August 2017

13549-13555

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Cell cycle checkpoint signaling through the ATM and ATR kinases

4 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

53BP1, a mediator of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

53BP1 is required for class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

The tandem BRCT domain of 53BP1 is not required for its repair function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Proteasome function is required for DNA damage response and fanconi anemia pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

The emerging role of bortezomib in the treatment of indolent non-Hodgkin's and mantle cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M710197200

21 January 2018

Identifiers

DOI

10.1074/JBC.M710197200

1 reference

4 August 2017

1 reference

PubMed ID

18337245