TGF-β signaling and the development of osteoarthritis (Q34763126)

4 August 2017

1 reference

title

TGF-β signaling and the development of osteoarthritis (English)

1 reference

4 August 2017

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Jie Shen

1

1 reference

4 August 2017

Shan Li

series ordinal

2

1 reference

4 August 2017

Di Chen

series ordinal

3

1 reference

4 August 2017

1 January 2014

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4 August 2017

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4 August 2017

2

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

4 August 2017

start time

27 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/boneres.2014.2

0 references

cites work

Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice

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7 July 2018

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

7 July 2018

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MMP13 is a critical target gene during the progression of osteoarthritis.

7 July 2018

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Aneurysm-osteoarthritis syndrome with visceral and iliac artery aneurysms

7 July 2018

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Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

7 July 2018

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The role of synovitis in osteoarthritis pathogenesis

7 July 2018

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Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

7 July 2018

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Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis.

7 July 2018

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A systems biology approach to synovial joint lubrication in health, injury, and disease

7 July 2018

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Osteoarthritis: an update with relevance for clinical practice

7 July 2018

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Camurati-Engelmann disease: unique variant featuring a novel mutation in TGFβ1 encoding transforming growth factor beta 1 and a missense change in TNFSF11 encoding RANK ligand

7 July 2018

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Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Osteoarthritis year 2010 in review: pathomechanisms

7 July 2018

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MicroRNA-140 plays dual roles in both cartilage development and homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Synovium-derived mesenchymal stem cells: a new cell source for musculoskeletal regeneration.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Etiopathogenesis of osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Endocytic regulation of TGF-beta signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Role of transforming growth factor-beta superfamily signaling pathways in human disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Association of the asporin D14 allele with lumbar-disc degeneration in Asians

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Extracellular control of TGFbeta signalling in vascular development and disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Bone morphogenetic protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

TGF-beta and osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Osteophytes: relevance and biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-beta1 to induce mesenchymal cell condensation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Aneurysm syndromes caused by mutations in the TGF-beta receptor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Clinical practice. Osteoarthritis of the knee

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Articular cartilage and osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Joint injury, repair, and remodeling: roles in post-traumatic osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Developmental regulation of the growth plate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

The role of bone metabolism in osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Two major Smad pathways in TGF-beta superfamily signalling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Promotion of embryonic chick limb cartilage differentiation by transforming growth factor-beta.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4274935

Transforming growth factor-beta1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in southern Chinese women.

7 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Asporin and knee osteoarthritis in patients of Greek origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Multiple aneurysms in a patient with aneurysms-osteoarthritis syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FBONERES.2014.2

Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone

21 January 2018

1 reference

12 December 2020

Subtyping of osteoarthritic synoviopathy

1 reference

12 December 2020

Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair

1 reference

12 December 2020

Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis

1 reference

12 December 2020

Association of transforming growth factor beta1 genotype with spinal osteophytosis in Japanese women

1 reference

12 December 2020

Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections

1 reference

12 December 2020

Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint

1 reference

12 December 2020

Pathophysiology of osteoarthritis

1 reference

12 December 2020

Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation

1 reference

12 December 2020

Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation

1 reference

12 December 2020

Identifiers

DOI

10.1038/BONERES.2014.2

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference

4 August 2017

1 reference