Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation (Q35025065)

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English	Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation	scientific article

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scholarly article

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Europe PubMed Central

5 August 2017

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation (English)

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5 August 2017

Alzheimer's disease

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1

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31 May 2020

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Monica Mariani

2

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31 May 2020

Lauren J Donovan

3

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31 May 2020

Lee Neilson

4

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31 May 2020

Gary E Landreth

5

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31 May 2020

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16 January 2015

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5 August 2017

Journal of Neuroinflammation

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31 May 2020

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31 May 2020

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31 May 2020

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Creative Commons Attribution 4.0 International

16 January 2015

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https://scigraph.springernature.com/pub.10.1186/s12974-014-0229-9

0 references

Neuroinflammation: the role and consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

1 reference

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8 July 2018

Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Activation of peroxisome proliferator-activated receptor-δ attenuates glutamate-induced neurotoxicity in HT22 mouse hippocampal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

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8 July 2018

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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8 July 2018

CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease

1 reference

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8 July 2018

Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease

1 reference

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8 July 2018

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

1 reference

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8 July 2018

Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

1 reference

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8 July 2018

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

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8 July 2018

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease.

1 reference

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8 July 2018

Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice

1 reference

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8 July 2018

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

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8 July 2018

Control of macrophage activation and function by PPARs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Alzheimer's Disease

1 reference

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8 July 2018

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

1 reference

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8 July 2018

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease

1 reference

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8 July 2018

Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation

1 reference

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8 July 2018

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice

1 reference

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8 July 2018

On the mechanism for PPAR agonists to enhance ABCA1 gene expression

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8 July 2018

Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo

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8 July 2018

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

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8 July 2018

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

1 reference

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8 July 2018

Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease

1 reference

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8 July 2018

Statistical analysis of real-time PCR data

1 reference

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8 July 2018

Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons.

1 reference

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8 July 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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8 July 2018

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

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8 July 2018

Roles of PPARs in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease

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8 July 2018

Up-regulated production and activation of the complement system in Alzheimer's disease brain

1 reference

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8 July 2018

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

1 reference

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8 July 2018

beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

8 July 2018

Complement activation by beta-amyloid in Alzheimer disease

1 reference

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8 July 2018

PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

1 reference

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21 January 2018

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

1 reference

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21 January 2018

Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury

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21 January 2018

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

1 reference

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21 January 2018

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

1 reference

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21 January 2018

Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease.

1 reference

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21 January 2018

Alzheimer's beta-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent manner.

1 reference

https://api.crossref.org/works/10.1186%2FS12974-014-0229-9

21 January 2018

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

1 reference

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21 January 2018

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

1 reference

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21 January 2018

Blockage of CR1 prevents activation of rodent microglia

1 reference

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21 January 2018

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation.

1 reference

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21 January 2018

NeuN is not a reliable marker of dopamine neurons in rat substantia nigra

1 reference

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21 January 2018

Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis.

1 reference

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21 January 2018

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4310027

25 October 2018

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10.1186/S12974-014-0229-9

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31 May 2020

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31 May 2020

1 reference

Europe PubMed Central

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31 May 2020

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