Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease (Q36208400)

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English	Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease	scientific article

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scholarly article

1 reference

Europe PubMed Central

12 August 2017

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

12 August 2017

Alzheimer's disease

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1 reference

based on heuristic

inferred from title

author name string

Shweta Mandrekar-Colucci

1

1 reference

Europe PubMed Central

12 August 2017

J Colleen Karlo

2

1 reference

Europe PubMed Central

12 August 2017

Gary E Landreth

3

1 reference

Europe PubMed Central

12 August 2017

language of work or name

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publication date

1 July 2012

1 reference

Europe PubMed Central

12 August 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

12 August 2017

32

1 reference

Europe PubMed Central

12 August 2017

10117-10128

1 reference

Europe PubMed Central

12 August 2017

30

1 reference

Europe PubMed Central

12 August 2017

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

Nuclear receptors as therapeutic targets for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

1 October 2017

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

1 reference

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1 October 2017

Neuroinflammatory processes in Alzheimer's disease

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1 October 2017

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

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1 October 2017

Control of macrophage activation and function by PPARs

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1 October 2017

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice

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1 October 2017

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

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1 October 2017

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin

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1 October 2017

Microglia and inflammation in Alzheimer's disease

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1 October 2017

Alzheimer's Disease

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1 October 2017

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease

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1 October 2017

PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance

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1 October 2017

Inflammation, microglia, and Alzheimer's disease

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1 October 2017

The role of apolipoprotein E in Alzheimer's disease

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1 October 2017

Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway

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1 October 2017

Exploring the full spectrum of macrophage activation

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1 October 2017

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

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1 October 2017

ApoE promotes the proteolytic degradation of Abeta

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1 October 2017

Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

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1 October 2017

Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins

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1 October 2017

Peroxisome proliferator-activated receptors--from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease

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1 October 2017

Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease.

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1 October 2017

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

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1 October 2017

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

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1 October 2017

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

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1 October 2017

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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1 October 2017

Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion

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1 October 2017

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

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1 October 2017

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

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1 October 2017

Neurovascular pathways and Alzheimer amyloid beta-peptide

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1 October 2017

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

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1 October 2017

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

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1 October 2017

The chemokine system in diverse forms of macrophage activation and polarization

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1 October 2017

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

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1 October 2017

ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I

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1 October 2017

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

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1 October 2017

Alternative activation of macrophages

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1 October 2017

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities

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1 October 2017

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

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1 October 2017

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

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1 October 2017

CD45: new jobs for an old acquaintance

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1 October 2017

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

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1 October 2017

Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice

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1 October 2017

Inflammation and Alzheimer's disease

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Cell mediators of inflammation in the Alzheimer disease brain

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Roles of PPARs in health and disease.

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1 October 2017

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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1 October 2017

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

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1 October 2017

Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain

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1 October 2017

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

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1 October 2017

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

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1 October 2017

Apolipoprotein E alleles as risk factors in Alzheimer's disease

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1 October 2017

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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1 October 2017

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

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1 October 2017

Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

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29 June 2018

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

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29 June 2018

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

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29 June 2018

Characterization of four lipoprotein classes in human cerebrospinal fluid

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29 June 2018

An ultrastructural study of the phagocytic activity of astrocytes in adult rat brain

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29 June 2018

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

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29 June 2018

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

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29 June 2018

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains.

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22 September 2018

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

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22 September 2018

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease.

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22 September 2018

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

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22 September 2018

Antagonist of peroxisome proliferator-activated receptor gamma induces cerebellar amyloid-beta levels and motor dysfunction in APP/PS1 transgenic mice.

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22 September 2018

Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus

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22 September 2018

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

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22 September 2018

Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

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22 September 2018

Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice

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22 September 2018

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

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22 September 2018

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

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22 September 2018

Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques.

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22 September 2018

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

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22 September 2018

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

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22 September 2018

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

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22 September 2018

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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22 September 2018

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.

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22 September 2018

Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).

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22 September 2018

High-yield isolation of murine microglia by mild trypsinization.

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22 September 2018

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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22 September 2018

Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microglia

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22 September 2018

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

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22 September 2018

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

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22 September 2018

Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites.

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22 September 2018

Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

22 September 2018

The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

22 September 2018

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

22 September 2018

Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433721

22 September 2018

Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/22836247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/22836247

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5268-11.2012

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

ResearchGate publication ID

0 references

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