Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum (Q35054195)

6 August 2017

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum (English)

1 reference

6 August 2017

1 reference

1 reference

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Jacques Corbeil

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Marc Ouellette

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Jean-François Ritt

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Philippe Leprohon

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Danielle Légaré

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

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publication date

21 November 2013

1 reference

PLoS Neglected Tropical Diseases

6 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

11

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9 June 2020

page(s)

e2564

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Creative Commons Attribution 4.0 International

9 June 2020

copyright license

start time

21 November 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

limma

object named as

LIMMA

2 references

22 June 2022

https://europepmc.org/article/PMC/3836990

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines

8 July 2018

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8 July 2018

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Genetic dissection of pyrimidine biosynthesis and salvage in Leishmania donovani

8 July 2018

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Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing

8 July 2018

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Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

8 July 2018

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Folate metabolic pathways in Leishmania

8 July 2018

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8 July 2018

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High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family

8 July 2018

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Fast and accurate long-read alignment with Burrows-Wheeler transform

8 July 2018

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8 July 2018

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The Sequence Alignment/Map format and SAMtools

8 July 2018

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Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.

8 July 2018

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5-Fluorouracil: mechanisms of resistance and reversal strategies

8 July 2018

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Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

8 July 2018

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The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells

8 July 2018

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Comparative genomic analysis of three Leishmania species that cause diverse human disease

8 July 2018

1 reference

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Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo

8 July 2018

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

8 July 2018

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Drug resistance in leishmaniasis

8 July 2018

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8 July 2018

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Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy

8 July 2018

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Molecular mechanisms of drug resistance

8 July 2018

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5-Fluorouracil: mechanisms of action and clinical strategies

8 July 2018

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Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

8 July 2018

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Pterin transport and metabolism in Leishmania and related trypanosomatid parasites

8 July 2018

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Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.

8 July 2018

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Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

8 July 2018

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Cloning of a novel inosine-guanosine transporter gene from Leishmania donovani by functional rescue of a transport-deficient mutant.

8 July 2018

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Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant

8 July 2018

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New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.

8 July 2018

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New mechanisms of drug resistance in parasitic protozoa

8 July 2018

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Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania

8 July 2018

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Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

8 July 2018

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Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

8 July 2018

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Purine and pyrimidine metabolism in parasitic protozoa

8 July 2018

1 reference

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The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene

8 July 2018

1 reference

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Gene amplification in Leishmania

8 July 2018

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A novel antifolate resistance gene on the amplified H circle of Leishmania.

8 July 2018

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8 July 2018

2 references

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21 January 2018

12 December 2020

Identification of the first pyrimidine nucleobase transporter in Leishmania: similarities with the Trypanosoma brucei U1 transporter and antileishmanial activity of uracil analogues.

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A new type of high affinity folic acid transporter in the protozoan parasite Leishmania and deletion of its gene in methotrexate-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0002564

Growth phase regulation of the main folate transporter of Leishmania infantum and its role in methotrexate resistance

21 January 2018

1 reference

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Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensis

21 January 2018

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Characterization of the folylpolyglutamate synthetase gene and polyglutamylation of folates in the protozoan parasite Leishmania

21 January 2018

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Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.

21 January 2018

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Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan

21 January 2018

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Functional expression and characterization of a purine nucleobase transporter gene from Leishmania major.

21 January 2018

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21 January 2018

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21 January 2018

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A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport.

21 January 2018

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Gene replacement in parasitic protozoa

25 October 2018

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UMP synthesis in the kinetoplastida

21 January 2018

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12 December 2020

Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania

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12 December 2020

[Furanosidase superfamily: search of homologues]

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12 December 2020

Nucleotide and polynucleotide synthesis in Trypanosoma cruzi. II. In vitro effect of tioguanine and of the aminonucleoside of stylomycin

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24278495%20AND%20SRC:MED&resulttype=core&format=json