Pathways to motor neuron degeneration in transgenic mouse models (Q35069437)

6 August 2017

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title

Pathways to motor neuron degeneration in transgenic mouse models (English)

1 reference

6 August 2017

4

Jean-Pierre Julien

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6 August 2017

Janice Robertson

1

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6 August 2017

Jasna Kriz

series ordinal

2

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6 August 2017

Minh Dang Nguyen

series ordinal

3

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6 August 2017

publication date

1 November 2002

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6 August 2017

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6 August 2017

volume

84

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6 August 2017

issue

11

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6 August 2017

page(s)

1151-1160

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Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression.

6 August 2017

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Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

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7 January 2021

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

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7 January 2021

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

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7 January 2021

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

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7 January 2021

Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)

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7 January 2021

Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis

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7 January 2021

Analysis of the KSP repeat of the neurofilament heavy subunit in familiar amyotrophic lateral sclerosis

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7 January 2021

Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis

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7 January 2021

A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene

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7 January 2021

Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E.

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7 January 2021

A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration

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7 January 2021

A structural scaffolding of intermediate filaments in health and disease

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7 January 2021

Neurofilaments in health and disease

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7 January 2021

Neurofilaments in health and disease

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7 January 2021

alpha-Internexin, a 66-kD intermediate filament-binding protein from mammalian central nervous tissues

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7 January 2021

Characterization of the mouse gene encoding the neuronal intermediate filament protein alpha-internexin

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7 January 2021

Peripherin, a new member of the intermediate filament protein family

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7 January 2021

Distribution of a novel 57 kDa intermediate filament (IF) protein in the nervous system.

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7 January 2021

Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during the development of the rat

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7 January 2021

Axotomy-induced changes in the expression of a type III neuronal intermediate filament gene

1 reference

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7 January 2021

Regulation of peripherin and neurofilament expression in regenerating rat motor neurons

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7 January 2021

Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis

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7 January 2021

SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.

1 reference

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7 January 2021

Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease

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7 January 2021

Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS).

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7 January 2021

Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments

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7 January 2021

Glutamate slows axonal transport of neurofilaments in transfected neurons

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7 January 2021

Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.

1 reference

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7 January 2021

Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord

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7 January 2021

Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Requirement of heavy neurofilament subunit in the development of axons with large calibers

1 reference

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7 January 2021

Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits

1 reference

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7 January 2021

No requirement of alpha-internexin for nervous system development and for radial growth of axons

1 reference

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7 January 2021

Electrophysiological properties of axons in mice lacking neurofilament subunit genes: disparity between conduction velocity and axon diameter in absence of NF-H.

1 reference

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7 January 2021

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

1 reference

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7 January 2021

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

1 reference

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7 January 2021

Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons.

1 reference

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7 January 2021

Altered ionic conductances in axons of transgenic mouse expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis

1 reference

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7 January 2021

Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit

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7 January 2021

Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice.

1 reference

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7 January 2021

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

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7 January 2021

Late onset of motor neurons in mice overexpressing wild-type peripherin

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7 January 2021

Neurofilament light and polyadenylated mRNA levels are decreased in amyotrophic lateral sclerosis motor neurons

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7 January 2021

Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

1 reference

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7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

The value of transgenic models for the study of neurodegenerative diseases

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https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase

1 reference

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7 January 2021

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

1 reference

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7 January 2021

Overexpression of neurofilament subunit NF-L and NF-H extends survival of a mouse model for amyotrophic lateral sclerosis

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7 January 2021

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1

1 reference

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7 January 2021

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

1 reference

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7 January 2021

Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

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7 January 2021

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Alterations in cyclin-dependent protein kinase 5 (CDK5) protein levels, activity and immunocytochemistry in canine motor neuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

1 reference

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7 January 2021

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

1 reference

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7 January 2021

Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Neuronophagia in the motor cortex in amyotrophic lateral sclerosis

1 reference

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7 January 2021

Neuropathology of ALS: an overview

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7 January 2021

Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis

1 reference

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7 January 2021

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

1 reference

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7 January 2021

Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis

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7 January 2021

Innate immunity: the missing link in neuroprotection and neurodegeneration?

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7 January 2021

Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.

1 reference

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7 January 2021

Neurodegenerative tauopathies

1 reference

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7 January 2021

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1 reference

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7 January 2021

Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments

1 reference

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7 January 2021

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

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7 January 2021

Dynactin increases the processivity of the cytoplasmic dynein motor

1 reference

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7 January 2021

Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end

1 reference

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7 January 2021

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

1 reference

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7 January 2021

Amyotrophic lateral sclerosis

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7 January 2021

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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7 January 2021

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Minocycline delays disease onset and mortality in a transgenic model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2802%2900025-1

7 January 2021

10.1016/S0300-9084(02)00025-1

Identifiers

DOI

1 reference

6 August 2017

1 reference