Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis (Q35084303)

6 August 2017

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title

Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis (English)

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6 August 2017

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Jean-Charles Fruchart

3

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Bart Staels

object named as

Bart Staels

4

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author name string

Lesley J Millatt

1

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PubMed ID

12633677

6 August 2017

Virginie Bocher

2

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PubMed ID

12633677

6 August 2017

language of work or name

English

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publication date

1 March 2003

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Biochimica et Biophysica Acta

6 August 2017

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6 August 2017

1631

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6 August 2017

2

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6 August 2017

107-118

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Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

LXR, a nuclear receptor that defines a distinct retinoid response pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Cholestenoic Acid Is a Naturally Occurring Ligand for Liver X Receptor α

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Role of LXRs in control of lipogenesis

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Higher levels of plasma cholesterol sulfate in patients with liver cirrhosis and hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Autoregulation of the human liver X receptor alpha promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Large scale gene expression analysis of cholesterol-loaded macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Oxidized phospholipids activate PPARα in a phospholipase A2-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Native LDL upregulation of ATP-binding cassette transporter-1 in human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Sterol regulatory element-binding protein-1c is responsible for cholesterol regulation of ileal bile acid-binding protein gene in vivo. Possible involvement of liver-X-receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Accumulation of foam cells in liver X receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytes

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https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Lipoprotein lipase increases low density lipoprotein retention by subendothelial cell matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900366-9

7 January 2021

10.1016/S1388-1981(02)00366-9

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12633677