RNA as a target for developing antivirals (Q35176024)

6 August 2017

RNA as a target for developing antivirals (English)

1 reference

6 August 2017

Kevin L McKnight

1

1 reference

PubMed ID

12856917

6 August 2017

Beverly A Heinz

series ordinal

2

1 reference

6 August 2017

1 March 2003

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Antiviral Chemistry & Chemotherapy

6 August 2017

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6 August 2017

14

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6 August 2017

2

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6 August 2017

61-73

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NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition

6 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

The binding mode of drugs to the TAR RNA of HIV-1 studied by electric linear dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Gene therapy. Intracellular immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Assays for poliovirus polymerase, 3D(Pol), and authentic RNA replication in HeLa S10 extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

A good antisense molecule is hard to find

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Inhibition of translation of hepatitis C virus RNA by 2-modified antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structure-based discovery of ligands targeted to the RNA double helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Progress in antisense technology: the end of the beginning

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Loop-loop interaction of HIV-1 TAR RNA with N3'-->P5' deoxyphosphoramidate aptamers inhibits in vitro Tat-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Emergence and selection of RNA virus variants: memory and extinction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structure elucidation of the hepatitis B virus encapsidation signal by NMR on selectively labeled RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Identification of a phosphodiester hexanucleotide that inhibits HIV-1 infection in vitro on covalent linkage of its 5'-end with a dimethoxytrityl residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeting RNA with small-molecule drugs: therapeutic promise and chemical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Short interfering RNA confers intracellular antiviral immunity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Selection and design of high-affinity RNA ligands for HIV-1 Rev.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

RNA as a drug target: chemical, modelling, and evolutionary tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Multiplexed screening of neutral mass-tagged RNA targets against ligand libraries with electrospray ionization FTICR MS: a paradigm for high-throughput affinity screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

A 1.3-A resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Modulation of HIV-1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

NMR study of 100 kDa HCV IRES RNA using segmental isotope labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

A potential RNA drug target in the hepatitis C virus internal ribosomal entry site

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Pharmacokinetics and tissue distribution of a ribozyme directed against hepatitis C virus RNA following subcutaneous or intravenous administration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeting the Tat-binding site of bovine immunodeficiency virus TAR RNA with a shape-selective rhodium complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

In vitro selection of RNA aptamers specific for cyanocobalamin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Vitamin B12 and hepatitis C: molecular biology and human pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

RNAPack: an integrated NMR approach to RNA structure determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

In vitro selection of HIV-1 TAR variants by the Tat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Footprinting, circular dichroism and UV melting studies on neomycin B binding to the packaging region of human immunodeficiency virus type-1 RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Molecular dynamics studies of the HIV-1 TAR and its complex with argininamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

siRNA-directed inhibition of HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Nucleic-acid therapeutics: basic principles and recent applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Structural change in Rev responsive element RNA of HIV-1 on binding Rev peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeting RNase L to human immunodeficiency virus RNA with 2-5A-antisense

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Inhibition of HIV-1 Rev-RRE interaction by diphenylfuran derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Inhibition of the self-cleavage reaction of the human hepatitis delta virus ribozyme by antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Measuring dissociation constants of RNA and aminoglycoside antibiotics by electrospray ionization mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

21 January 2018

RNA interference--2001.

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Selective RNA cleavage by isolated RNase L activated with 2-5A antisense chimeric oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

The origin of hepatitis C virus genotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Selection of RNA aptamers that bind specifically to the NS3 protease of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Hammerhead ribozyme engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Targeting RNA with small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Inhibition of the HIV-1 rev-RRE complex formation by unfused aromatic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Sequence requirements for viral RNA replication and VPg uridylylation directed by the internal cis-acting replication element (cre) of human rhinovirus type 14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

A molecular mechanics investigation of RNA complexes. I. Ethidium intercalation in an HIV-1 TAR RNA sequence with an unpaired adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Modulation of the Rev-RRE interaction by aromatic heterocyclic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Genetic analysis of a poliovirus/hepatitis C virus chimera: new structure for domain II of the internal ribosomal entry site of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

Stem-loop SL4 of the HIV-1 Ψ RNA packaging signal exhibits weak affinity for the nucleocapsid protein. structural studies and implications for genome recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020301400201

10.1177/095632020301400201

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12856917