Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains (Q35180699)

7 August 2017

title

Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains (English)

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7 August 2017

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4

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7 August 2017

Jennifer Y Lee

1

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7 August 2017

Yu-Hsin Chiu

series ordinal

2

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7 August 2017

John Asara

series ordinal

3

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7 August 2017

language of work or name

English

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publication date

8 August 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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7 August 2017

volume

108

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7 August 2017

issue

34

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7 August 2017

page(s)

14157-14162

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

7 August 2017

cites work

1 reference

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A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

13 July 2018

1 reference

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E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells

13 July 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

13 July 2018

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

13 July 2018

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

13 July 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

13 July 2018

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The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

13 July 2018

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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

13 July 2018

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A rapid method for determining protein kinase phosphorylation specificity

13 July 2018

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Protein kinase D signaling

13 July 2018

1 reference

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The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins

13 July 2018

1 reference

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

13 July 2018

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The protein kinase complement of the human genome

13 July 2018

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

13 July 2018

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Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway

13 July 2018

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Role of the PI3K regulatory subunit in the control of actin organization and cell migration

13 July 2018

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p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K

13 July 2018

1 reference

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

13 July 2018

1 reference

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

13 July 2018

1 reference

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Determination of the specific substrate sequence motifs of protein kinase C isozymes

13 July 2018

1 reference

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Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

Use of an oriented peptide library to determine the optimal substrates of protein kinases

13 July 2018

1 reference

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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

SH2 domains recognize specific phosphopeptide sequences

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

Highly conserved eight amino acid sequence in SH2 is important for recognition of phosphotyrosine site

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer

13 July 2018

1 reference

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Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3161555

Biochemistry. PI3K charges ahead

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21825134

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1107747108

1 reference

7 August 2017

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7 August 2017

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