Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice (Q35581474)

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scientific article published on 19 March 2015

Language	Label	Description	Also known as
English	Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice	scientific article published on 19 March 2015

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scholarly article

1 reference

9 August 2017

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice (English)

1 reference

9 August 2017

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pharmacokinetics

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based on heuristic

inferred from title

pharmacodynamics

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based on heuristic

inferred from title

object named as

Roberto Calle

9

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author name string

Yan Weng

1

1 reference

9 August 2017

Jeffrey R Chabot

2

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9 August 2017

Barbara Bernardo

3

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9 August 2017

Qingyun Yan

4

1 reference

9 August 2017

Yimin Zhu

5

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9 August 2017

Martin B Brenner

6

1 reference

9 August 2017

Chandra Vage

7

1 reference

9 August 2017

Alison Logan

8

1 reference

9 August 2017

Saswata Talukdar

10

1 reference

9 August 2017

language of work or name

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publication date

19 March 2015

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9 August 2017

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9 August 2017

10

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9 August 2017

e0119104

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9 August 2017

3

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9 August 2017

copyright license

Creative Commons Attribution 4.0 International

19 March 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.

1 reference

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12 July 2018

FGF21-based pharmacotherapy--potential utility for metabolic disorders

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NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids

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12 July 2018

FGF21 mimetic shows therapeutic promise.

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12 July 2018

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

1 reference

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Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody

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Exploring mechanisms of FGF signalling through the lens of structural biology

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Fundamentals of FGF19 & FGF21 action in vitro and in vivo

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Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex

1 reference

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

1 reference

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FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents

1 reference

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A guide to analysis of mouse energy metabolism

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12 July 2018

Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in Chinese

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FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

1 reference

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FGF21 reloaded: challenges of a rapidly growing field

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Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

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Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

1 reference

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Fibroblast growth factor 21: from pharmacology to physiology

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Estimating the continuous-time dynamics of energy and fat metabolism in mice

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Different roles of N- and C- termini in the functional activity of FGF21

1 reference

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FGF21 N- and C-termini play different roles in receptor interaction and activation

1 reference

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Serum levels of the adipokine FGF21 depend on renal function

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Fibroblast growth factor 21 corrects obesity in mice

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What is the required energy deficit per unit weight loss?

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Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

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FGF-21 as a novel metabolic regulator

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Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

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Identifiers

10.1371/JOURNAL.PONE.0119104

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9 August 2017

2015PLoSO..1019104W

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release_2axoufd5offn7icfextdsblt3m

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https://api.fatcat.wiki/v0/release/2axoufd5offn7icfextdsblt3m

24 November 2022

based on heuristic

mapped directly with Wikidata item

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9 August 2017

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9 August 2017

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