Mechanisms of Abeta clearance and catabolism (Q35625628)

9 August 2017

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title

Mechanisms of Abeta clearance and catabolism (English)

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9 August 2017

Suzanne Y Guénette

1

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PubMed ID

14716023

9 August 2017

language of work or name

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1 January 2003

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9 August 2017

NeuroMolecular Medicine

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9 August 2017

4

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9 August 2017

3

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9 August 2017

147-160

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https://scigraph.springernature.com/pub.10.1385/nmm:4:3:147

9 August 2017

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cites work

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

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12 December 2020

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

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12 December 2020

Declining expression of neprilysin in Alzheimer disease vasculature: possible involvement in cerebral amyloid angiopathy

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12 December 2020

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.

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12 December 2020

Degradation of amylin by insulin-degrading enzyme

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12 December 2020

Degradation of intraendosomal insulin by insulin-degrading enzyme without acidification

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12 December 2020

Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

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12 December 2020

Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

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12 December 2020

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

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12 December 2020

Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes

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12 December 2020

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

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12 December 2020

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

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12 December 2020

Role of insulin and insulin receptor in learning and memory

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12 December 2020

A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease

1 reference

12 December 2020

The rat insulin-degrading enzyme. Molecular cloning and characterization of tissue-specific transcripts.

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12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

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12 December 2020

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42.

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12 December 2020

Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues

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12 December 2020

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

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12 December 2020

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

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12 December 2020

Regulation of amyloid beta-peptide levels by enzymatic degradation.

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12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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12 December 2020

Age at onset in two common neurodegenerative diseases is genetically controlled

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Susceptibility locus for Alzheimer's disease on chromosome 10.

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12 December 2020

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

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12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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12 December 2020

Mutant genes in familial Alzheimer's disease and transgenic models

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12 December 2020

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

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12 December 2020

Enkephalin metabolism by microglial aminopeptidase N (CD13)

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12 December 2020

Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.

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12 December 2020

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

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12 December 2020

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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12 December 2020

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

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12 December 2020

Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin

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12 December 2020

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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12 December 2020

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

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12 December 2020

Endopeptidase-24.11 is the integral membrane peptidase initiating degradation of somatostatin in the hippocampus

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12 December 2020

The role of microglia in Alzheimer's disease: friend or foe?

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12 December 2020

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

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12 December 2020

Association of insulin-degrading enzyme with a 70 kDa cytosolic protein in hepatoma cells

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12 December 2020

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

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12 December 2020

Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample.

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12 December 2020

Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells

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12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

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12 December 2020

Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo.

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

Clearing the brain's amyloid cobwebs

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12 December 2020

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization

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12 December 2020

Intraendosomal degradation of transforming growth factor alpha

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12 December 2020

Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D

1 reference

12 December 2020

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

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12 December 2020

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

1 reference

12 December 2020

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).

1 reference

12 December 2020

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

1 reference

12 December 2020

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

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12 December 2020

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

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12 December 2020

Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition

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12 December 2020

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology

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12 December 2020

Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme

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12 December 2020

Metabolic regulation of brain Abeta by neprilysin.

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12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

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12 December 2020

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

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12 December 2020

Insulin-degrading enzyme: embarking on amyloid destruction.

1 reference

12 December 2020

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

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12 December 2020

Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.

1 reference

12 December 2020

Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins

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12 December 2020

Endothelin-converting enzymes and endothelin receptor B messenger RNAs are expressed in different neural cell species and these messenger RNAs are coordinately induced in neurons and astrocytes respectively following nerve injury

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme.

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12 December 2020

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.

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12 December 2020

Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid beta catabolism

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12 December 2020

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

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12 December 2020

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

1 reference

12 December 2020

Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line

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12 December 2020

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

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12 December 2020

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

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12 December 2020

New frontiers in Alzheimer's disease genetics

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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12 December 2020

Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX.

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12 December 2020

Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis

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12 December 2020

Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

1 reference

12 December 2020

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

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12 December 2020

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Ontogeny, regional and cellular distribution of the novel metalloprotease neprilysin 2 in the rat: a comparison with neprilysin and endothelin-converting enzyme-1

1 reference

12 December 2020

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

12 December 2020

Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling

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12 December 2020

Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide.

1 reference

12 December 2020

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.

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12 December 2020

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

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12 December 2020

1 reference

12 December 2020

CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation

1 reference

12 December 2020

Insulin degradation: progress and potential

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12 December 2020

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

1 reference

12 December 2020

Identifiers

DOI

10.1385/NMM:4:3:147

1 reference

PubMed ID

14716023

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

14716023