Translating cancer 'omics' to improved outcomes (Q35694365)

9 August 2017

title

Translating cancer 'omics' to improved outcomes (English)

1 reference

9 August 2017

Emily A Vucic

1

1 reference

9 August 2017

Kelsie L Thu

2

1 reference

9 August 2017

Keith Robison

3

1 reference

9 August 2017

Leszek A Rybaczyk

4

1 reference

9 August 2017

Raj Chari

5

1 reference

9 August 2017

Carlos E Alvarez

6

1 reference

9 August 2017

Wan L Lam

7

1 reference

9 August 2017

publication date

1 February 2012

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9 August 2017

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9 August 2017

volume

22

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9 August 2017

issue

2

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9 August 2017

page(s)

188-195

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The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations

9 August 2017

cites work

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12 July 2018

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12 July 2018

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DNA secondary structures and epigenetic determinants of cancer genome evolution

12 July 2018

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Reduced lung-cancer mortality with low-dose computed tomographic screening

12 July 2018

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Personalized medicine: new genomics, old lessons

12 July 2018

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Use of whole-genome sequencing to diagnose a cryptic fusion oncogene

12 July 2018

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Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.

12 July 2018

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American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy.

12 July 2018

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Dog models of naturally occurring cancer

12 July 2018

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Initial genome sequencing and analysis of multiple myeloma

12 July 2018

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Mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small-cell lung cancer: clinical and molecular considerations

12 July 2018

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Molecular profiling of cancer--the future of personalized cancer medicine: a primer on cancer biology and the tools necessary to bring molecular testing to the clinic

12 July 2018

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Interactome networks and human disease

12 July 2018

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Computational analysis of high throughput sequencing data

12 July 2018

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Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene

12 July 2018

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Breast cancer genome heterogeneity: a challenge to personalised medicine?

12 July 2018

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Cancer evolution and individual susceptibility

12 July 2018

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How genetically engineered mouse tumor models provide insights into human cancers

12 July 2018

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Mutant BRAF melanomas--dependence and resistance

12 July 2018

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12 July 2018

Bring on the biomarkers

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Identifying cancer driver genes in tumor genome sequencing studies

12 July 2018

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Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?

12 July 2018

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ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time

12 July 2018

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Deconstructing the molecular portraits of breast cancer

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?

12 July 2018

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Patient-oriented gene set analysis for cancer mutation data

12 July 2018

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Man's best friend becomes biology's best in show: genome analyses in the domestic dog

12 July 2018

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

12 July 2018

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Breast cancer assessment tools and optimizing adjuvant therapy.

12 July 2018

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Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer

12 July 2018

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The NIH Roadmap Epigenomics Mapping Consortium

12 July 2018

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Accumulation of driver and passenger mutations during tumor progression

12 July 2018

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

12 July 2018

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A simple genetic architecture underlies morphological variation in dogs

12 July 2018

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Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors

12 July 2018

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The challenge of selecting the 'right' in vivo oncology pharmacology model

12 July 2018

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Systems biology and the discovery of diagnostic biomarkers

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.

12 July 2018

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Application of second-generation sequencing to cancer genomics

12 July 2018

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International network of cancer genome projects

12 July 2018

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Personal genomes in progress: from the human genome project to the personal genome project

12 July 2018

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

12 July 2018

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Targeted therapy for gastrointestinal stromal tumors: current status and future perspectives

12 July 2018

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Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer

12 July 2018

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In silico functional profiling of human disease-associated and polymorphic amino acid substitutions

12 July 2018

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Complex landscapes of somatic rearrangement in human breast cancer genomes

12 July 2018

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A small-cell lung cancer genome with complex signatures of tobacco exposure

12 July 2018

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Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.

12 July 2018

1 reference

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KEGG for representation and analysis of molecular networks involving diseases and drugs

12 July 2018

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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells

12 July 2018

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Oncogenic activating mutations are associated with local copy gain

12 July 2018

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

12 July 2018

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Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines

12 July 2018

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American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

12 July 2018

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Translation of the Philadelphia chromosome into therapy for CML.

12 July 2018

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Mapping DNA structural variation in dogs

12 July 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

12 July 2018

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K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

12 July 2018

1 reference

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APC and the three-hit hypothesis

12 July 2018

1 reference

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Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer.

12 July 2018

1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

12 July 2018

1 reference

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Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

The cancer biomarker problem

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution

12 July 2018

1 reference

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

12 July 2018

1 reference

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Trastuzumab--mechanism of action and use in clinical practice

12 July 2018

1 reference

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Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

12 July 2018

1 reference

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Statistical analysis of pathogenicity of somatic mutations in cancer

12 July 2018

1 reference

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The personal genome project

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Systems biology and new technologies enable predictive and preventative medicine.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

The case for early detection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

CpG methylation reduces genomic instability.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Lung carcinoma in former smokers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Cancer biomarkers: closer to delivering on their promise

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Germline fitness-based scoring of cancer mutations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Microsatellite instability analysis and its correlation with hMLH1 repair gene hypermethylation status in esophageal pathologies including cancers.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Gain and loss of phosphorylation sites in human cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Selection for genome instability by DNA damage in human cells: unstable microsatellites and their consequences for tumourigenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3266027

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

25 September 2018

1 reference

12 December 2020

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

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12 December 2020

Patterns of Absolute Risk of Lung Cancer Mortality in Former Smokers

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12 December 2020

The evolving war on cancer

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12 December 2020

EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- and prospective observations in non-small-cell lung cancer

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12 December 2020

A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointestinal stromal tumors

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12 December 2020

Whole-genome sequencing: a step closer to personalized medicine

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12 December 2020

Chromosome studies in human leukemia. II. Chronic granulocytic leukemia

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12 December 2020

Cancer genomics: from discovery science to personalized medicine

1 reference

12 December 2020

Identifiers

DOI

10.1101/GR.124354.111

1 reference

9 August 2017

1 reference

9 August 2017

1 reference