Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia (Q35712192)

9 August 2017

Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia (English)

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9 August 2017

lymphoblastic leukemia

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van der Burg M

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Poulsen TS

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Hunger SP

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Beverloo HB

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Smit EM

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Langerak AW

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van Dongen JJ

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1 May 2004

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895-908

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403340

9 August 2017

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Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.

21 January 2018

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A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia.

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Translocation t(5;14)(q35;q32) in three cases of childhood T cell acute lymphoblastic leukemia: a new recurring and cryptic abnormality

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

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HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.

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Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia

21 January 2018

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Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

21 January 2018

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Minimal residual disease in leukaemia patients

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Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

21 January 2018

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The impact of the new fish technologies on the cytogenetics of haematological malignancies

21 January 2018

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A single split-signal FISH probe set allows detection of TAL1 translocations as well as SIL-TAL1 fusion genes in a single test.

21 January 2018

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Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias

21 January 2018

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Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpoints

21 January 2018

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Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms

21 January 2018

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Retroposons--seeds of evolution

21 January 2018

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SINEs and LINEs: Highly repeated short and long interspersed sequences in mammalian genomes

21 January 2018

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Human genome organization: Alu, LINES, and the molecular structure of metaphase chromosome bands

21 January 2018

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Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

21 January 2018

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PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules

21 January 2018

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Balanced and unbalanced 1;19 translocation-associated acute lymphoblastic leukemias

21 January 2018

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Molecular analysis of the t(1;19) breakpoint cluster region in pre-B cell acute lymphoblastic leukemias

21 January 2018

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Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

21 January 2018

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The role of E2A-PBX1 in leukemogenesis

21 January 2018

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Gradient of E2A activity in B-cell development

21 January 2018

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Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

21 January 2018

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Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia

21 January 2018

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E2A-HLF usurps control of evolutionarily conserved survival pathways

21 January 2018

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A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

21 January 2018

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Hematologic malignancies with t(4;11)(q21;q23)--a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants.

21 January 2018

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

21 January 2018

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 January 2018

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11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

21 January 2018

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

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Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias

21 January 2018

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Genomic organization of TEL: the human ETS-variant gene 6.

21 January 2018

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Relapse of TEL-AML1--positive acute lymphoblastic leukemia in childhood: a matched-pair analysis.

21 January 2018

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ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia

21 January 2018

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The biology of chronic myeloid leukemia

21 January 2018

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Modeling Philadelphia chromosome positive leukemias

21 January 2018

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Bcr encodes a GTPase-activating protein for p21rac

21 January 2018

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Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation

21 January 2018

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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

21 January 2018

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Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

21 January 2018

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Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions.

21 January 2018

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TAL1 expression does not occur in the majority of T-ALL blasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

21 January 2018

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Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

21 January 2018

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Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease.

21 January 2018

1 reference

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Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

21 January 2018

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Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences

21 January 2018

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High incidence of Hox11L2 expression in children with T-ALL.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Identification of a novel putative Ran-binding protein and its close homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Detection of illegitimate rearrangement within the immunoglobulin locus on 14q32.3 in B-cell malignancies using end-sequenced probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Molecular cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Mll rearrangements in haematological malignancies: lessons from clinical and biological studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Acute myelogenous leukemia with the t(3;12)(q26;p13) translocation: case report and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

A novel cryptic translocation t(12;17)(p13;p12-p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Involvement of the MLL gene in T-lineage acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Detection of illegitimate rearrangements within the immunoglobulin light chain loci in B cell malignancies using end sequenced probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

An atlas of chromosomes in hematological malignancies. Example: 11q23 and MLL partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

E2A-PBX1 fusion in adult acute lymphoblastic leukaemia: biological and clinical features

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Comparison of cytogenetics, Southern blotting, and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in children with acute leukemia and with 11q23 abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23; p13) or its derivative

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Detection of E2A translocations in leukemias via fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patients. European 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Hematological malignancies with t(9;11)(p21-22;q23)--a laboratory and clinical study of 125 cases. European 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The t(10;11)(p12;q23) translocation in acute leukaemia: a cytogenetic and clinical study of 20 patients. European 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases. EU Concerted Action 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Derivative chromosomes of 11q23-translocations in hematologic malignancies. European 11q23 Workshop participants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Cytogenetic abnormalities associated with the t(12;21): a collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Expression profile of wild-type ETV6 in childhood acute leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Unique forms of the abl tyrosine kinase distinguish Ph1-positive CML from Ph1-positive ALL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Simultaneous SIL-TAL1 RT-PCR detection of all tal(d) deletions and identification of novel tal(d) variants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Visualization of mono-allelic chromosomal aberrations 3' and 5' of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403340

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403340

1 reference

Dimensions Publication ID

9 August 2017

0 references

1 reference