CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus (Q35751063)

10 August 2017

title

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus (English)

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10 August 2017

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Ling Zhao

1

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10 August 2017

Jennifer L Cannons

2

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10 August 2017

Stacie Anderson

3

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10 August 2017

Martha Kirby

4

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10 August 2017

Liping Xu

5

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10 August 2017

Lucio H Castilla

6

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10 August 2017

Pamela L Schwartzberg

7

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10 August 2017

Rémy Bosselut

8

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10 August 2017

P Paul Liu

9

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10 August 2017

language of work or name

English

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publication date

21 December 2006

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10 August 2017

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10 August 2017

volume

109

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10 August 2017

issue

8

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10 August 2017

page(s)

3432-3440

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The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3.

10 August 2017

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12 July 2018

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12 July 2018

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Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

12 July 2018

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AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression

12 July 2018

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12 July 2018

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12 July 2018

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

12 July 2018

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Cbfbeta interacts with Runx2 and has a critical role in bone development

12 July 2018

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Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11

12 July 2018

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12 July 2018

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Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta

12 July 2018

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Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

12 July 2018

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12 July 2018

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Indispensable role of the transcription factor PEBP2/CBF in angiogenic activity of a murine endothelial cell MSS31.

12 July 2018

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

12 July 2018

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Solution structure of core binding factor beta and map of the CBF alpha binding site

12 July 2018

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12 July 2018

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Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

12 July 2018

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The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

12 July 2018

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

12 July 2018

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Identification of clonogenic common lymphoid progenitors in mouse bone marrow

12 July 2018

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

12 July 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

12 July 2018

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

12 July 2018

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

12 July 2018

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

12 July 2018

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

12 July 2018

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Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha

12 July 2018

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

12 July 2018

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PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

12 July 2018

1 reference

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A transcriptional silencer controls the developmental expression of the CD4 gene.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Cbfβ is involved in maturation of all lineages of hematopoietic cells during embryogenesis except erythroid

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1852246

Clonality analysis of cell lineages in acute myeloid leukemia with inversion 16

25 September 2018

1 reference

12 December 2020

Dissociation of cytokine signals for proliferation and apoptosis

1 reference

12 December 2020

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia

1 reference

12 December 2020

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

1 reference

12 December 2020

Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development

1 reference

12 December 2020

10.1182/BLOOD-2006-10-051508

Identifiers

DOI

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10 August 2017

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10 August 2017

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