Prion diseases--close to effective therapy? (Q35906120)

11 August 2017

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title

Prion diseases--close to effective therapy? (English)

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11 August 2017

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2

Byron Caughey

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11 August 2017

1

Neil R Cashman

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11 August 2017

1 October 2004

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Nature Reviews Drug Discovery

11 August 2017

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11 August 2017

3

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11 August 2017

10

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11 August 2017

874-884

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https://scigraph.springernature.com/pub.10.1038/nrd1525

11 August 2017

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cites work

1755 and all that: a historical primer of transmissible spongiform encephalopathy

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Protease-resistant prion protein produced in vitro lacks detectable infectivity.

21 January 2018

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PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease

21 January 2018

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The immunobiology of TSE diseases.

21 January 2018

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Synthesis and trafficking of prion proteins in cultured cells

21 January 2018

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

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Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions

21 January 2018

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Drug therapy in human and experimental transmissible spongiform encephalopathy

21 January 2018

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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study

21 January 2018

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CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER: A SPONGIFORM ENCEPHALOPATHY

21 January 2018

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Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells

21 January 2018

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A new variant of Creutzfeldt-Jakob disease in the UK.

21 January 2018

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Updated projections of future vCJD deaths in the UK

31 March 2020

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Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion.

31 March 2020

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Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model

31 March 2020

1 reference

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

31 March 2020

1 reference

Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent

31 March 2020

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The same prion strain causes vCJD and BSE

31 March 2020

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Implications of BSE infection screening data for the scale of the British BSE epidemic and current European infection levels.

31 March 2020

1 reference

Bovine spongiform encephalopathy in sheep?

31 March 2020

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BSE - a wolf in sheep's clothing?

31 March 2020

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BSE in sheep bred for resistance to infection

31 March 2020

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Chronic wasting disease and potential transmission to humans

31 March 2020

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Self-replication and scrapie

31 March 2020

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Novel proteinaceous infectious particles cause scrapie

31 March 2020

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31 March 2020

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The new biology of spongiform encephalopathy: infectious amyloidoses with a genetic twist

31 March 2020

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Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

31 March 2020

1 reference

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

31 March 2020

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NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

31 March 2020

1 reference

A cellular gene encodes scrapie PrP 27-30 protein

31 March 2020

1 reference

Separation and properties of cellular and scrapie prion proteins

31 March 2020

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Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines.

31 March 2020

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Nearly ubiquitous tissue distribution of the scrapie agent precursor protein.

31 March 2020

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Molecular biology of prion diseases

31 March 2020

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A kinetic model for amyloid formation in the prion diseases: importance of seeding

31 March 2020

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Cell-free formation of protease-resistant prion protein.

31 March 2020

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Non-genetic propagation of strain-specific properties of scrapie prion protein.

31 March 2020

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Interactions and conversions of prion protein isoforms

31 March 2020

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Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

31 March 2020

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Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

31 March 2020

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A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

31 March 2020

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Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state

31 March 2020

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Partial unfolding and refolding of scrapie-associated prion protein: evidence for a critical 16-kDa C-terminal domain.

31 March 2020

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Eight prion strains have PrP(Sc) molecules with different conformations

31 March 2020

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Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

31 March 2020

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Mutant PrPSc conformers induced by a synthetic peptide and several prion strains

31 March 2020

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Synthetic mammalian prions

31 March 2020

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Mice devoid of PrP are resistant to scrapie

31 March 2020

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Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents

31 March 2020

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Early accumulation of pathological PrP in the enteric nervous system and gut-associated lymphoid tissue of hamsters orally infected with scrapie

31 March 2020

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The role of the spleen in the neuroinvasion of scrapie in mice

31 March 2020

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Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues

31 March 2020

1 reference

Follicular dendritic cells in TSE pathogenesis

31 March 2020

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Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

31 March 2020

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A crucial role for B cells in neuroinvasive scrapie.

31 March 2020

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Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

31 March 2020

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Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

31 March 2020

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Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

31 March 2020

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Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.

31 March 2020

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PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice

31 March 2020

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Current concepts and controversies in prion immunopathology

31 March 2020

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Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.

31 March 2020

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Complement facilitates early prion pathogenesis.

31 March 2020

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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

31 March 2020

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Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

31 March 2020

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Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation.

31 March 2020

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Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies.

31 March 2020

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Monoclonal antibodies inhibit prion replication and delay the development of prion disease

31 March 2020

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Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

31 March 2020

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Signal transduction through prion protein

31 March 2020

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Cellular isoform of the scrapie agent protein participates in lymphocyte activation

31 March 2020

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Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state

31 March 2020

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A prion protein epitope selective for the pathologically misfolded conformation

31 March 2020

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

31 March 2020

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The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits

31 March 2020

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Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

31 March 2020

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Characterization of scrapie infection in mouse neuroblastoma cells

31 March 2020

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Evidence for the multiplication of scrapie agent in cell culture.

31 March 2020

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Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents

31 March 2020

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PrP polymorphisms tightly control sheep prion replication in cultured cells

31 March 2020

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New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products

31 March 2020

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Branched polyamines cure prion-infected neuroblastoma cells

31 March 2020

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Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

31 March 2020

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A solid-phase assay for identification of modulators of prion protein interactions

31 March 2020

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Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain.

31 March 2020

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Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

31 March 2020

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Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

31 March 2020

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Studies on peptide fragments of prion proteins.

31 March 2020

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Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form

31 March 2020

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Prion protein conversion in vitro

31 March 2020

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Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

31 March 2020

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Effectiveness of anthracycline against experimental prion disease in Syrian hamsters.

31 March 2020

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Tetracyclines affect prion infectivity

31 March 2020

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Dimethyl sulfoxide delays PrP sc accumulation and disease symptoms in prion-infected hamsters

31 March 2020

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Dextran Sulphate 500 Delays and Prevents Mouse Scrapie by Impairment of Agent Replication in Spleen

31 March 2020

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Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection.

31 March 2020

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Porphyrin and phthalocyanine antiscrapie compounds.

31 March 2020

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Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies

31 March 2020

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Evaluation of quinacrine treatment for prion diseases

31 March 2020

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Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen

31 March 2020

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Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

31 March 2020

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Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent

31 March 2020

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Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

31 March 2020

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Chemoprophylaxis of scrapie in mice

31 March 2020

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Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fate

31 March 2020

1 reference

Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein

31 March 2020

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Cellular heparan sulfate participates in the metabolism of prions

31 March 2020

1 reference

RNA molecules stimulate prion protein conversion

31 March 2020

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Prion diseases: a nucleic-acid accomplice?

31 March 2020

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Potent inhibition of scrapie-associated PrP accumulation by congo red

31 March 2020

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The anti-prion activity of Congo red. Putative mechanism

31 March 2020

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Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

31 March 2020

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Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin

31 March 2020

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Prophylactic and therapeutic effects of phthalocyanine tetrasulfonate in scrapie-infected mice

31 March 2020

1 reference

Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters.

31 March 2020

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Approaches to prophylaxis and therapy

31 March 2020

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Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.

31 March 2020

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Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release

31 March 2020

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MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters

31 March 2020

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Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

31 March 2020

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Copper chelation delays the onset of prion disease

31 March 2020

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Chimeric prion protein expression in cultured cells and transgenic mice

31 March 2020

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Interactions between heterologous forms of prion protein: binding, inhibition of conversion, and species barriers

31 March 2020

1 reference

PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie

31 March 2020

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Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

31 March 2020

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

31 March 2020

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Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides

31 March 2020

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Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models

31 March 2020

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Results of quinacrine administration to patients with Creutzfeldt-Jakob disease.

31 March 2020

1 reference

Inactivation of transmissible degenerative encephalopathy agents: A review

31 March 2020

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Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice

31 March 2020

1 reference

Specific inhibition of pathological prion protein accumulation by small interfering RNAs

31 March 2020

1 reference

Shattuck lecture--neurodegenerative diseases and prions

31 March 2020

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

31 March 2020

1 reference

The antiviral compound HPA-23 can prevent scrapie when administered at the time of infection

31 March 2020

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Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1525

1 reference

11 August 2017

1 reference

PubMed ID

15459678