A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells (Q35909947)

11 August 2017

A transendocytosis model of CTLA-4 function predicts its suppressive behavior on regulatory T cells (English)

1 reference

11 August 2017

6

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1 June 2020

David M Sansom

7

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1 June 2020

author name string

Tie Zheng Hou

1

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1 June 2020

Omar S Qureshi

2

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1 June 2020

Chun Jing Wang

3

1 reference

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1 June 2020

Jennifer Baker

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25632005%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Stephen P Young

5

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1 June 2020

language of work or name

English

0 references

publication date

28 January 2015

1 reference

11 August 2017

Journal of Immunology

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1 June 2020

volume

194

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1 June 2020

page(s)

2148-2159

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1 June 2020

issue

5

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describes a project that uses

1 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4522736/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

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Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

11 July 2018

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The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes

11 July 2018

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Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells

11 July 2018

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Constitutive clathrin-mediated endocytosis of CTLA-4 persists during T cell activation

11 July 2018

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11 July 2018

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11 July 2018

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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

11 July 2018

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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

11 July 2018

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

11 July 2018

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

11 July 2018

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Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis

11 July 2018

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CTLA-4 control over Foxp3+ regulatory T cell function

11 July 2018

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Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation

11 July 2018

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Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

11 July 2018

1 reference

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Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

11 July 2018

1 reference

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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

11 July 2018

1 reference

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11 July 2018

The B7 family revisited

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An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

11 July 2018

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CD4+CD28- costimulation-independent T cells in multiple sclerosis

11 July 2018

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Toll-like receptors: critical proteins linking innate and acquired immunity

11 July 2018

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Dendritic cells as sensors of infection.

11 July 2018

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Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40.

11 July 2018

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Structural analysis of CTLA-4 function in vivo

11 July 2018

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

11 July 2018

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11 July 2018

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Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression

11 July 2018

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CTLA-4 ligation blocks CD28-dependent T cell activation

11 July 2018

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CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity

11 July 2018

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B70 antigen is a second ligand for CTLA-4 and CD28.

11 July 2018

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

11 July 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

11 July 2018

1 reference

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

11 July 2018

1 reference

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Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

11 July 2018

1 reference

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

11 July 2018

1 reference

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T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

The reverse stop-signal model for CTLA4 function.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

CTLA4Ig: bridging the basic immunology with clinical application

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

B7-independent inhibition of T cells by CTLA-4.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4522736

CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25632005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

B7/CD28 but not LFA-3/CD2 interactions can provide 'third-party' co-stimulation for human T-cell activation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25632005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1401876

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25632005%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25632005%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25632005%20AND%20SRC:MED&resulttype=core&format=json