Targeted deletion reveals an essential function for the telomere length regulator Trf1. (Q35920252)

11 August 2017

Targeted deletion reveals an essential function for the telomere length regulator Trf1. (English)

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11 August 2017

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Titia de Lange

7

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Tyler Jacks

6

object named as

Tyler Jacks

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11 August 2017

Jan Karlseder

1

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11 August 2017

Leili Kachatrian

2

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11 August 2017

Hiroyuki Takai

3

1 reference

11 August 2017

Kim Mercer

4

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11 August 2017

Sunil Hingorani

5

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11 August 2017

language of work or name

English

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publication date

1 September 2003

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Molecular and Cellular Biology

11 August 2017

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11 August 2017

23

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18

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6533-6541

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describes a project that uses

11 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC193696/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

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"Stemness": transcriptional profiling of embryonic and adult stem cells

11 July 2018

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Different telomere damage signaling pathways in human and mouse cells

11 July 2018

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

11 July 2018

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Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Senescence Induced by Altered Telomere State, Not Telomere Loss

11 July 2018

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Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

11 July 2018

1 reference

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Haploinsufficiency of mTR results in defects in telomere elongation

11 July 2018

1 reference

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Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

11 July 2018

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New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

11 July 2018

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Protection of mammalian telomeres

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

SALL1, the gene mutated in Townes-Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin

11 July 2018

1 reference

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A critical role for Pin2/TRF1 in ATM-dependent regulation. Inhibition of Pin2/TRF1 function complements telomere shortening, radiosensitivity, and the G(2)/M checkpoint defect of ataxia-telangiectasia cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

DNA-PKcs is critical for telomere capping

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Switching and signaling at the telomere

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Ku acts in a unique way at the mammalian telomere to prevent end joining

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

11 July 2018

1 reference

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

11 July 2018

1 reference

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Control of human telomere length by TRF1 and TRF2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

TIN2, a new regulator of telomere length in human cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Ku is associated with the telomere in mammals

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

TRF1 binds a bipartite telomeric site with extreme spatial flexibility

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Severe growth defect in mouse cells lacking the telomerase RNA component

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Association of nucleoside diphosphate kinase nm23-H2 with human telomeres

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Telomeric localization of TRF2, a novel human telobox protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

TRF1 is a dimer and bends telomeric DNA

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Control of telomere length by the human telomeric protein TRF1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Tumor spectrum analysis in p53-mutant mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

A human telomeric protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=193696

Tankyrase promotes telomere elongation in human cells

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12944479

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12944479

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.23.18.6533-6541.2003

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

12944479

1 reference