Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor. (Q35925841)

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18 February 2020

title

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor (English)

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18 February 2020

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procollagen-proline 4-dioxygenase complex

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Christopher J. Schofield

7

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18 February 2020

Holger B. Kramer

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18 February 2020

James S. McCullagh

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18 February 2020

Emily Flashman

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18 February 2020

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Hanna Tarhonskaya

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18 February 2020

author name string

Adam P Hardy

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18 February 2020

Emily A Howe

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18 February 2020

Nikita D Loik

4

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language of work or name

English

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publication date

25 June 2015

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Journal of Biological Chemistry

18 February 2020

published in

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18 February 2020

volume

290

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18 February 2020

issue

32

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18 February 2020

page(s)

19726-19742

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Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel

18 February 2020

cites work

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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

2 October 2017

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Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

2 October 2017

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2 October 2017

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Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.

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2 October 2017

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2 October 2017

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Inverse solvent isotope effects demonstrate slow aquo release from hypoxia inducible factor-prolyl hydroxylase (PHD2)

2 October 2017

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2 October 2017

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Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates

2 October 2017

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Hypoxia. Cross talk between oxygen sensing and the cell cycle machinery

2 October 2017

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Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

2 October 2017

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Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

2 October 2017

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Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model

2 October 2017

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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

2 October 2017

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

2 October 2017

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FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

2 October 2017

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Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

2 October 2017

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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

2 October 2017

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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

2 October 2017

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Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

2 October 2017

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Evidence for a stereoelectronic effect in human oxygen sensing.

2 October 2017

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Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

2 October 2017

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2 October 2017

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Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

2 October 2017

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Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

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The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

2 October 2017

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2 October 2017

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Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

2 October 2017

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

2 October 2017

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

2 October 2017

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Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

2 October 2017

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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

2 October 2017

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Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

2 October 2017

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

2 October 2017

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Oxygen sensing by HIF hydroxylases

2 October 2017

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FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

2 October 2017

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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

2 October 2017

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

2 October 2017

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

2 October 2017

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Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

2 October 2017

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A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics

2 October 2017

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

2 October 2017

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Consensus-derived structural determinants of the ankyrin repeat motif

2 October 2017

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Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

2 October 2017

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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

2 October 2017

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Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

2 October 2017

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

2 October 2017

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

2 October 2017

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HIF-1 and mechanisms of hypoxia sensing

2 October 2017

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Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

2 October 2017

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Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

24 September 2018

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Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

24 September 2018

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Kinetic dissection of the catalytic mechanism of taurine:alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

24 September 2018

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The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

24 September 2018

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The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

24 September 2018

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Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

24 September 2018

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Crossref

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Mechanism of Taurine: α-Ketoglutarate Dioxygenase (TauD) fromEscherichia coli

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M115.653014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26112411%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26112411%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1 reference