GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α (Q35959502)

11 August 2017

GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α (English)

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11 August 2017

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1 reference

2

Agnes Görlach

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11 August 2017

Daniela Flügel

1

1 reference

11 August 2017

Thomas Kietzmann

series ordinal

3

1 reference

11 August 2017

language of work or name

English

0 references

publication date

5 December 2011

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11 August 2017

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11 August 2017

119

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11 August 2017

5

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11 August 2017

1292-1301

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describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3352078/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation

2 October 2017

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2 October 2017

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An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

2 October 2017

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Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

2 October 2017

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2 October 2017

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

2 October 2017

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Function and regulation of cullin-RING ubiquitin ligases

2 October 2017

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

2 October 2017

1 reference

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Inactivation of hCDC4 can cause chromosomal instability

2 October 2017

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

2 October 2017

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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.

2 October 2017

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hCDC4 gene mutations in endometrial cancer

2 October 2017

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

2 October 2017

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

2 October 2017

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

2 October 2017

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

2 October 2017

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

2 October 2017

1 reference

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2 October 2017

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2 October 2017

The renaissance of GSK3

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

2 October 2017

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2 October 2017

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

2 October 2017

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

2 October 2017

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

2 October 2017

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

2 October 2017

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Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

2 October 2017

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Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

2 October 2017

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

2 October 2017

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Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes

2 October 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

2 October 2017

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3352078

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22144179

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2011-08-375014

1 reference

11 August 2017

1 reference

11 August 2017

1 reference