The tumor suppressor gene TP53: implications for cancer management and therapy (Q35986418)

11 August 2017

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title

The tumor suppressor gene TP53: implications for cancer management and therapy (English)

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11 August 2017

5

Pierre Hainaut

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11 August 2017

Severine Seemann

1

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11 August 2017

Daniela Maurici

series ordinal

2

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11 August 2017

Magali Olivier

series ordinal

3

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11 August 2017

Claude Caron de Fromentel

series ordinal

4

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11 August 2017

1 January 2004

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Critical Reviews in Clinical Laboratory Sciences

11 August 2017

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11 August 2017

41

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11 August 2017

5-6

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11 August 2017

551-583

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

11 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Characterization of the human p53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Genotoxic and non-genotoxic pathways of p53 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Radical causes of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The role of p53-target genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Role in tumorigenesis of silent mutations in the TP53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Dominant-negative p53 mutations selected in yeast hit cancer hot spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: a phase I study of p53 gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Radiation enhances the anti-tumor effects of vaccinia-p53 gene therapy in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Evaluation of combined vaccinia virus-mediated antitumor gene therapy with p53, IL-2, and IL-12 in a glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Cancer gene therapy mediated by CTS1, a p53 derivative: advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Potentiation of radiation therapy by the oncolytic adenovirus dl1520 (ONYX-015) in human malignant glioma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin beta3 subunit expression and increased by reconstitution of integrin alphavbeta3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Why did p53 gene therapy fail in ovarian cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Zinc binding and redox control of p53 structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Redox signalling and transition metals in the control of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Role of infection as a risk factor for atherosclerosis, myocardial infarction, and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Temperature-dependent switching between "wild-type" and "mutant" forms of p53-Val135.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Single-chain antibody against the common epitope of mutant p53: isolation and intracytosolic expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

ASPP proteins specifically stimulate the apoptotic function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

An information-intensive approach to the molecular pharmacology of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Microsatellite alterations in plasma DNA of small cell lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Microsatellite alterations in serum DNA of head and neck cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Presence of fetal DNA in maternal plasma and serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360490504952

10.1080/10408360490504952

21 January 2018

Identifiers

DOI

1 reference

11 August 2017

1 reference