Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. (Q34443272)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446780%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence (English)

1 reference

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15 December 2019

4

1 reference

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15 December 2019

author name string

Alberto Inga

series ordinal

1

1 reference

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15 December 2019

Francesca Storici

series ordinal

2

1 reference

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15 December 2019

Thomas A Darden

series ordinal

3

1 reference

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15 December 2019

language of work or name

English

0 references

publication date

1 December 2002

1 reference

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Molecular and Cellular Biology

15 December 2019

published in

1 reference

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15 December 2019

volume

22

1 reference

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15 December 2019

issue

24

1 reference

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15 December 2019

page(s)

8612-8625

1 reference

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The p53MH algorithm and its application in detecting p53-responsive genes

15 December 2019

cites work

1 reference

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Why is p53 acetylated?

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

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hADA3 is required for p53 activity

6 July 2018

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ASPP proteins specifically stimulate the apoptotic function of p53

6 July 2018

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

6 July 2018

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6 July 2018

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DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.

6 July 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

6 July 2018

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

6 July 2018

1 reference

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Kinetics of p53 binding to promoter sites in vivo

6 July 2018

1 reference

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6 July 2018

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Genome-wide location and function of DNA binding proteins

6 July 2018

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6 July 2018

Surfing the p53 network

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

6 July 2018

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Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

6 July 2018

1 reference

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

6 July 2018

1 reference

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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

6 July 2018

1 reference

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Definition of the p53 functional domains necessary for inducing apoptosis

6 July 2018

1 reference

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p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest

6 July 2018

1 reference

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

6 July 2018

1 reference

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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

6 July 2018

1 reference

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Stress signals utilize multiple pathways to stabilize p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

6 July 2018

1 reference

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

6 July 2018

1 reference

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Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis

6 July 2018

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

6 July 2018

1 reference

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Regulation of the p53 tumor suppressor protein

6 July 2018

1 reference

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Identification and classification of p53-regulated genes

6 July 2018

1 reference

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One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

6 July 2018

1 reference

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Increased apoptosis induction by 121F mutant p53

6 July 2018

1 reference

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Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter.

6 July 2018

1 reference

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

6 July 2018

1 reference

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Regulation of p53 downstream genes.

6 July 2018

1 reference

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The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

How p53 binds DNA as a tetramer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential

6 July 2018

1 reference

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DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.

6 July 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Transcriptional activation by recruitment

6 July 2018

1 reference

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p53, the cellular gatekeeper for growth and division

6 July 2018

1 reference

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Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

6 July 2018

1 reference

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6 July 2018

p53: puzzle and paradigm

1 reference

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Dominant-negative p53 mutations selected in yeast hit cancer hot spots

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

6 July 2018

1 reference

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Allosteric activation of latent p53 tetramers

6 July 2018

1 reference

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p53 tagged sites from human genomic DNA.

6 July 2018

1 reference

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Studies on the transformation of intact yeast cells by the LiAc/SS-DNA/PEG procedure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites

6 July 2018

1 reference

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A simple p53 functional assay for screening cell lines, blood, and tumors

6 July 2018

1 reference

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Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Discrimination of DNA binding sites by mutant p53 proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

Selection of DNA binding sites by regulatory proteins. Statistical-mechanical theory and application to operators and promoters.

6 July 2018

1 reference

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Mammalian p53 can function as a transcription factor in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

6 July 2018

1 reference

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Definition of a consensus binding site for p53

6 July 2018

1 reference

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

6 July 2018

1 reference

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27 October 2018

To bind or not to bind.

1 reference

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In vivo site-directed mutagenesis using oligonucleotides

27 October 2018

1 reference

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Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

27 October 2018

1 reference

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TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

27 October 2018

1 reference

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p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

27 October 2018

1 reference

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Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=139870

CA/TG sequence at the 5' end of oligo(A)-tracts strongly modulates DNA curvature

27 October 2018

1 reference

12 December 2020

Prognostic significance ofp53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay

1 reference

12 December 2020

How cells choose to die

1 reference

12 December 2020

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

12 December 2020

p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements

1 reference

12 December 2020

Structure-based rescue of common tumor-derived p53 mutants

1 reference

12 December 2020

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

12 December 2020

Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53

1 reference

12 December 2020

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

12 December 2020

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

1 reference

12 December 2020

Galactose as a gratuitous inducer of GAL gene expression in yeasts growing on glucose

1 reference

12 December 2020

10.1128/MCB.22.24.8612-8625.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446780%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12446780%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference