Molecular pathogenesis of astrocytic tumours (Q36021558)

11 August 2017

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title

Molecular pathogenesis of astrocytic tumours (English)

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11 August 2017

Koichi Ichimura

1

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11 August 2017

Hiroko Ohgaki

series ordinal

2

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11 August 2017

Paul Kleihues

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3

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11 August 2017

V Peter Collins

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4

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11 August 2017

1 November 2004

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Journal of Neuro-Oncology

11 August 2017

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11 August 2017

70

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11 August 2017

2

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11 August 2017

137-160

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https://scigraph.springernature.com/pub.10.1007/s11060-004-2747-2

11 August 2017

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Long-term follow-up of von Recklinghausen neurofibromatosis. Survival and malignant neoplasms.

21 January 2018

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A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Deletion mapping of chromosome 10 in human glioma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Loss of heterozygosity on chromosome 19 in secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Genetic profile of gliosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Pleomorphic xanthoastrocytoma: what do we really know about it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Genetic alterations commonly found in diffusely infiltrating cerebral gliomas are rare or absent in pleomorphic xanthoastrocytomas.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11060-004-2747-2

Rare mutations of the DMBT1 gene in human astrocytic gliomas

21 January 2018

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12 December 2020

Intracranial gliomas in neurofibromatosis type 1.

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12 December 2020

Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function

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12 December 2020

Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features

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12 December 2020

Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas.

1 reference

12 December 2020

The complexity of the 7p12 amplicon in human astrocytic gliomas: detailed mapping of 246 tumors.

1 reference

12 December 2020

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

1 reference

12 December 2020

The diagnosis and management of neurofibromatosis 2 in childhood

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12 December 2020

Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas.

1 reference

12 December 2020

Brain tumors in familial adenomatous polyposis

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12 December 2020

Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.

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12 December 2020

Mapping of the chromosome 19 q-arm glioma tumor suppressor gene using fluorescence in situ hybridization and novel microsatellite markers

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12 December 2020

Optic gliomas in children with neurofibromatosis type 1

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12 December 2020

A cytogenetic study of 53 human gliomas.

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12 December 2020

Germline hMSH2 and differential somatic mutations in patients with Turcot's syndrome.

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12 December 2020

p14ARF links the tumour suppressors RB and p53.

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12 December 2020

A region of common deletion in 22q13.3 in human glioma associated with astrocytoma progression.

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12 December 2020

Fine mapping of a region of common deletion on chromosome arm 10p in human glioma.

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12 December 2020

Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p

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12 December 2020

Molecular genetic alterations in pleomorphic xanthoastrocytoma

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12 December 2020

Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis.

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12 December 2020

Brain, other central nervous system, and eye cancer.

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12 December 2020

Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation.

1 reference

12 December 2020

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

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12 December 2020

Molecular classification of human diffuse gliomas by multidimensional scaling analysis of gene expression profiles parallels morphology-based classification, correlates with survival, and reveals clinically-relevant novel glioma subsets

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12 December 2020

Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

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12 December 2020

The cell cycle kinases

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12 December 2020

Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme.

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12 December 2020

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

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12 December 2020

Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.

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12 December 2020

Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.

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12 December 2020

Relationship between gene amplification and chromosomal deviations in malignant human gliomas

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12 December 2020

Genetic and environmental factors in the etiology of human brain tumors

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12 December 2020

Localization of common deletion regions on 1p and 19q in human gliomas and their association with histological subtype.

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12 December 2020

Expression of the CD34 antigen in pleomorphic xanthoastrocytomas.

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12 December 2020

Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours

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12 December 2020

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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12 December 2020

A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.

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12 December 2020

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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12 December 2020

Chromosomal imbalance maps of malignant solid tumors: a cytogenetic survey of 3185 neoplasms

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12 December 2020

Molecular genetic analysis of giant cell glioblastomas

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12 December 2020

Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma.

1 reference

12 December 2020

Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling

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12 December 2020

Epigenetic changes in pilocytic astrocytomas and medulloblastomas.

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12 December 2020

Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma

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12 December 2020

Absence of mutation of the p73 gene in astrocytic neoplasms.

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12 December 2020

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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12 December 2020

Gene amplification as a prognostic factor in primary brain tumors.

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12 December 2020

Subsets of glioblastoma multiforme defined by molecular genetic analysis.

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12 December 2020

DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours

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12 December 2020

Loss of heterozygosity at 11p15 in malignant glioma.

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12 December 2020

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

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12 December 2020

A role for receptor tyrosine phosphatase zeta in glioma cell migration

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12 December 2020

Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex.

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12 December 2020

Analysis of theNF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas

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12 December 2020

Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours

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12 December 2020

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene.

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12 December 2020

Treatment and survival of low-grade astrocytoma in adults--1977-1988

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12 December 2020

DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer

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12 December 2020

Decision making by p53: life, death and cancer

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12 December 2020

Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

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12 December 2020

Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas.

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12 December 2020

p14ARF deletion and methylation in genetic pathways to glioblastomas.

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12 December 2020

Common regions of deletion on chromosome 22q12.3-q13.1 and 22q13.2 in human astrocytomas appear related to malignancy grade.

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12 December 2020

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors

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12 December 2020

Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes.

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12 December 2020

Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q.

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12 December 2020

Identification of combination gene sets for glioma classification.

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12 December 2020

High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours

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12 December 2020

Loss of genetic information in central nervous system tumors common to children and young adults.

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12 December 2020

Chromosomal instability and p53 inactivation are required for genesis of glioblastoma but not for colorectal cancer in patients with germline mismatch repair gene mutation.

1 reference

12 December 2020

Amplification of alpha-platelet-derived growth factor receptor gene lacking an exon coding for a portion of the extracellular region in a primary brain tumor of glial origin

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12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

The risk of brain tumours in hereditary non-polyposis colorectal cancer (HNPCC).

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12 December 2020

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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12 December 2020

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors

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12 December 2020

Rb-mediated chromatin structure regulation and transcriptional repression

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12 December 2020

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors

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12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

12 December 2020

Microsatellite deletion mapping on chromosome 10q and mutation analysis of MMAC1, FAS, and MXI1 in human glioblastoma multiforme.

1 reference

12 December 2020

DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.

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12 December 2020

Differential gene expression profiling in human brain tumors

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12 December 2020

p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas.

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12 December 2020

Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.

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12 December 2020

The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy

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12 December 2020

Microsatellite instability and the PTEN1 gene mutation in a subset of early onset gliomas carrying germline mutation or promoter methylation of the hMLH1 gene.

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12 December 2020

p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency

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12 December 2020

Assembly of microarrays for genome-wide measurement of DNA copy number

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12 December 2020

Gene expression profiling identifies molecular subtypes of gliomas

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12 December 2020

Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies.

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12 December 2020

Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.

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12 December 2020

Specific chromosomal abnormalities in malignant human gliomas.

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12 December 2020

p53 mutations versus EGF receptor expression in giant cell glioblastomas

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12 December 2020

Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus.

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12 December 2020

Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19.

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12 December 2020

Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.

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12 December 2020

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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12 December 2020

Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors.

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12 December 2020

MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells

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12 December 2020

The molecular basis of Turcot's syndrome

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12 December 2020

Chromosome 7 rearrangements in glioblastomas; loci adjacent to EGFR are independently amplified.

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12 December 2020

Analysis of pilocytic astrocytoma by comparative genomic hybridization.

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12 December 2020

Loss of heterozygosity of chromosome 10p in human gliomas.

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12 December 2020

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

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12 December 2020

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

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12 December 2020

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification

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12 December 2020

Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosity on chromosome 3p in human glial tumors.

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12 December 2020

Promoter hypermethylation of the RB1 gene in glioblastomas.

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12 December 2020

Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma.

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12 December 2020

Chromosomal characteristics of childhood brain tumors

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12 December 2020

Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.

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12 December 2020

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

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12 December 2020

PKB/AKT: functional insights from genetic models

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12 December 2020

Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.

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12 December 2020

Somatic mutations of PTEN in glioblastoma multiforme.

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12 December 2020

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.

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12 December 2020

Alterations of the TP53 gene in human gliomas.

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12 December 2020

Distinct methylation profiles of glioma subtypes.

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12 December 2020

Microsatellite instability occurs in distinct subtypes of pediatric but not adult central nervous system tumors

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12 December 2020

bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status.

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12 December 2020

Comparative genomic hybridization in glioma: a meta-analysis of 509 cases.

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12 December 2020

EGF receptor amplification and expression in human brain tumours

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12 December 2020

Identification of molecular subtypes of glioblastoma by gene expression profiling.

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12 December 2020

Chromosome 17 abnormalities and lack of TP53 mutations in paediatric central nervous system tumours

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12 December 2020

Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials

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12 December 2020

PTEN mutations in gliomas and glioneuronal tumors.

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12 December 2020

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

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12 December 2020

Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas.

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12 December 2020

Are juvenile pilocytic astrocytomas benign tumors? A cytogenetic study in 24 cases.

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12 December 2020

Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.

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12 December 2020

Optic chiasmatic-hypothalamic glioma

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12 December 2020

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12 December 2020

Short postoperative survival for glioblastoma patients with a dysfunctional Rb1 pathway in combination with no wild-type PTEN.

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12 December 2020

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor

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12 December 2020

Identification of allelic loss on chromosome arm 6p in human astrocytomas by arbitrarily primed polymerase chain reaction.

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12 December 2020

Methylation of the p73 gene in gliomas

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12 December 2020

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

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12 December 2020

PI3K/Akt and apoptosis: size matters

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12 December 2020

Duodenal carcinoid tumours, phaeochromocytoma and neurofibromatosis: islet cell tumour, phaeochromocytoma and the von Hippel-Lindau complex: two distinctive neuroendocrine syndromes

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12 December 2020

Incidence of germ-line p53 mutations in patients with gliomas.

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12 December 2020

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

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12 December 2020

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

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12 December 2020

Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells.

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12 December 2020

Structural alterations of the epidermal growth factor receptor gene in human gliomas

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12 December 2020

Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.

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12 December 2020

A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications

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12 December 2020

Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis.

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12 December 2020

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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12 December 2020

Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas.

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12 December 2020

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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12 December 2020

Mutation analysis of the hCHK2 gene in primary human malignant gliomas.

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12 December 2020

Gene expression-based classification of malignant gliomas correlates better with survival than histological classification.

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12 December 2020

Second neoplasms after acute lymphoblastic leukemia in childhood.

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12 December 2020

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

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12 December 2020

EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins

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12 December 2020

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification

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12 December 2020

A transcript map of the chromosome 19q-arm glioma tumor suppressor region

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12 December 2020

KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas

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12 December 2020

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

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12 December 2020

Deletion of p16 and p15 genes in brain tumors

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12 December 2020

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas

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12 December 2020

Clonal genomic alterations in glioma malignancy stages.

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12 December 2020

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

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12 December 2020

10.1007/S11060-004-2747-2

Identifiers

DOI

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11 August 2017

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