LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2). (Q36023320)

11 August 2017

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2). (English)

1 reference

Ras homolog enriched in brain Dmel_CG1081

11 August 2017

1 reference

Target of rapamycin Dmel_CG5092

1 reference

Raptor Dmel_CG4320

1 reference

Lst8 Dmel_CG3004

1 reference

Tsc1 Dmel_CG6147

1 reference

author name string

Tao Wang

1

1 reference

11 August 2017

Rachel Blumhagen

2

1 reference

11 August 2017

Uyen Lao

3

1 reference

11 August 2017

Ying Kuo

4

1 reference

11 August 2017

Bruce A Edgar

5

1 reference

11 August 2017

language of work or name

English

0 references

publication date

9 April 2012

1 reference

Molecular and Cellular Biology

11 August 2017

1 reference

11 August 2017

32

1 reference

11 August 2017

12

1 reference

11 August 2017

2203-2213

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3372270/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Activation of mTORC2 by association with the ribosome

2 October 2017

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Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

2 October 2017

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mTOR: from growth signal integration to cancer, diabetes and ageing

2 October 2017

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

2 October 2017

1 reference

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Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

2 October 2017

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Structure of the human mTOR complex I and its implications for rapamycin inhibition.

2 October 2017

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

2 October 2017

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

2 October 2017

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Rictor is a novel target of p70 S6 kinase-1.

2 October 2017

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TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease

2 October 2017

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Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

2 October 2017

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Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

2 October 2017

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Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1

2 October 2017

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

2 October 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

2 October 2017

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Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex

2 October 2017

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P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

2 October 2017

1 reference

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

2 October 2017

1 reference

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

2 October 2017

1 reference

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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

2 October 2017

1 reference

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Localization of Rheb to the endomembrane is critical for its signaling function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

TOR signaling in growth and metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Rheb binds and regulates the mTOR kinase

2 October 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

2 October 2017

1 reference

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2 October 2017

1 reference

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Role and regulation of starvation-induced autophagy in the Drosophila fat body

2 October 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

2 October 2017

1 reference

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

2 October 2017

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2 October 2017

1 reference

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

2 October 2017

1 reference

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LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

2 October 2017

1 reference

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Ends-out, or replacement, gene targeting in Drosophila

2 October 2017

1 reference

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Akt regulates growth by directly phosphorylating Tsc2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Flow cytometric analysis of Drosophila cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

A phosphoinositide synthase required for a sustained light response.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

A nutrient sensor mechanism controls Drosophila growth.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372270

Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22493059

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structure of TOR and Its Complex with KOG1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22493059

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.06474-11

1 reference

11 August 2017

1 reference

11 August 2017

1 reference