Rational targeting of Notch signaling in cancer (Q37256451)

19 August 2017

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title

Rational targeting of Notch signaling in cancer (English)

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19 August 2017

P Rizzo

1

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19 August 2017

C Osipo

2

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19 August 2017

K Foreman

3

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19 August 2017

T Golde

4

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19 August 2017

B Osborne

5

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19 August 2017

L Miele

6

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19 August 2017

language of work or name

English

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publication date

1 September 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

5124-5131

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19 August 2017

38

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https://scigraph.springernature.com/pub.10.1038/onc.2008.226

19 August 2017

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cites work

Notch signaling in cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch and Ikaros: not only converging players in T cell leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Targeting transcription factors in acute leukemia in children

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch: control of lymphocyte differentiation in the periphery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Correlating notch signaling with thymocyte maturation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

High-level JAG1 mRNA and protein predict poor outcome in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch1 and notch2 have opposite effects on embryonal brain tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Mammary stem cells and breast cancer--role of Notch signalling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Structural basis for autoinhibition of Notch

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

31 March 2020

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch and cancer: a double-edged sword

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Gamma-secretase: proteasome of the membrane?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch: a unique therapeutic target for immunomodulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch signaling in cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Regulation of acquired immune system by notch signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Regulation of Notch signalling by non-visual beta-arrestin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch and NOXA-related pathways in melanoma cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch1 functions as a tumor suppressor in mouse skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Regulation of notch signaling by o-linked fucose.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Off the beaten pathway: the complex cross talk between Notch and NF-kappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The many faces of Notch signaling in skin-derived cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The multifaceted role of Notch in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

p66Shc/Notch-3 interplay controls self-renewal and hypoxia survival in human stem/progenitor cells of the mammary gland expanded in vitro as mammospheres

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Numb is an endocytic protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch signaling, gamma-secretase inhibitors, and cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Cancer stem cells--an old idea that's new again: implications for the diagnosis and treatment of breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Notch signaling is an important regulator of type 2 immunity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Involvement of Notch signaling in hippocampal synaptic plasticity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Glucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Molecular determinants of NOTCH4 transcription in vascular endothelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Delta-like 4/Notch signaling and its therapeutic implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.226

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.226

1 reference

19 August 2017

1 reference