Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis (Q36026661)

11 August 2017

Metformin: an emerging new therapeutic option for targeting cancer stem cells and metastasis (English)

1 reference

11 August 2017

1 reference

neoplastic stem cells

1 reference

Ramandeep Rattan

1

1 reference

PMCID

3373168

11 August 2017

Rouba Ali Fehmi

series ordinal

2

1 reference

PMCID

3373168

11 August 2017

Adnan Munkarah

series ordinal

3

1 reference

11 August 2017

4 June 2012

1 reference

11 August 2017

1 reference

11 August 2017

2012

1 reference

11 August 2017

928127

1 reference

Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice

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Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

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Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

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A perspective on cancer cell metastasis

2 October 2017

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Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins

2 October 2017

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Metformin and cancer: new applications for an old drug

2 October 2017

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Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis

2 October 2017

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Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells

2 October 2017

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Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.

2 October 2017

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The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells.

2 October 2017

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Expression and functional significance of HtrA1 loss in endometrial cancer

2 October 2017

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Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

2 October 2017

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Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

2 October 2017

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Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer

2 October 2017

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Metformin prevents tobacco carcinogen--induced lung tumorigenesis

2 October 2017

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Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated [...]

2 October 2017

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2 October 2017

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Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer

2 October 2017

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The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

2 October 2017

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Epidermal growth factor-induced epithelial-mesenchymal transition in human esophageal carcinoma cells--a model for the study of metastasis

2 October 2017

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Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

2 October 2017

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Neoplastic stem cells: current concepts and clinical perspectives.

2 October 2017

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The therapeutic promise of the cancer stem cell concept

2 October 2017

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Epithelial-mesenchymal transitions in development and disease

2 October 2017

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Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

2 October 2017

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Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner

2 October 2017

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Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy

2 October 2017

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Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review

2 October 2017

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Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

2 October 2017

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2 October 2017

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The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

2 October 2017

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A "latent niche" mechanism for tumor initiation

2 October 2017

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

2 October 2017

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Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells

2 October 2017

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

2 October 2017

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Antidiabetic therapies affect risk of pancreatic cancer

2 October 2017

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Metformin, insulin, breast cancer and more...

2 October 2017

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Human induced pluripotent stem cells free of vector and transgene sequences

2 October 2017

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Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells

2 October 2017

1 reference

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The epithelial-mesenchymal transition-inducing factor TWIST is an attractive target in advanced and/or metastatic bladder and prostate cancers

2 October 2017

1 reference

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The regulation and function of mammalian AMPK-related kinases.

2 October 2017

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The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies

2 October 2017

1 reference

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Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin induces apoptosis of pancreatic cancer cells

2 October 2017

1 reference

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Sulphonylureas and cancer: a case-control study

2 October 2017

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Efficient tumour formation by single human melanoma cells

2 October 2017

1 reference

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Generation of breast cancer stem cells through epithelial-mesenchymal transition

2 October 2017

1 reference

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Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.

2 October 2017

1 reference

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

2 October 2017

1 reference

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The epithelial-mesenchymal transition generates cells with properties of stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells

2 October 2017

1 reference

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The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

2 October 2017

1 reference

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Generation of pluripotent stem cells from adult mouse liver and stomach cells

2 October 2017

1 reference

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Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Identification of cells initiating human melanomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

2 October 2017

1 reference

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Induced pluripotent stem cell lines derived from human somatic cells

2 October 2017

1 reference

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Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

2 October 2017

1 reference

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Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Preparing the "soil": the premetastatic niche

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Identification and expansion of human colon-cancer-initiating cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Complex networks orchestrate epithelial-mesenchymal transitions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis

2 October 2017

1 reference

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

2 October 2017

1 reference

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin and reduced risk of cancer in diabetic patients

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Identification of human brain tumour initiating cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Prospective identification of tumorigenic breast cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

The blooming of the French lilac

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Mouse snail is a target gene for HIF.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Role of AMP-activated protein kinase in autophagy and proteasome function

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Prevention of pancreatic cancer induction in hamsters by metformin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373168

Low triglyceride and nonuse of statins is associated with cancer in type 2 diabetes mellitus

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2012%2F928127

Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22701483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22701483

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2012/928127

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3373168