Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma (Q36071514)

12 August 2017

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma (English)

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12 August 2017

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Satoshi Kawano

1

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12 August 2017

Alexandra R Grassian

2

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12 August 2017

Masumi Tsuda

3

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12 August 2017

Sarah K Knutson

4

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12 August 2017

Natalie M Warholic

5

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12 August 2017

Galina Kuznetsov

6

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12 August 2017

Shanqin Xu

7

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12 August 2017

Yonghong Xiao

8

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12 August 2017

Roy M Pollock

9

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12 August 2017

Jesse S Smith

10

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12 August 2017

Kevin K Kuntz

11

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12 August 2017

Scott Ribich

12

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12 August 2017

Yukinori Minoshima

13

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12 August 2017

Junji Matsui

14

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12 August 2017

Robert A Copeland

15

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12 August 2017

Shinya Tanaka

16

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12 August 2017

Heike Keilhack

17

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12 August 2017

language of work or name

English

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publication date

8 July 2016

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12 August 2017

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12 August 2017

11

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12 August 2017

7

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12 August 2017

e0158888

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Creative Commons Attribution 4.0 International

12 August 2017

start time

8 July 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4938529

inferred from PubMed Central ID database lookup

cites work

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro

1 reference

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EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

2 October 2017

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Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy

2 October 2017

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2 October 2017

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The expanding family of SMARCB1(INI1)-deficient neoplasia: implications of phenotypic, biological, and molecular heterogeneity

2 October 2017

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Molecular pathways: protein methyltransferases in cancer

2 October 2017

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Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma

2 October 2017

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

2 October 2017

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Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

2 October 2017

1 reference

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Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma

2 October 2017

1 reference

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The spectrum of SWI/SNF mutations, ubiquitous in human cancers

2 October 2017

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Combinatorial complexity in chromatin structure and function: revisiting the histone code

2 October 2017

1 reference

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Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics

2 October 2017

1 reference

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

2 October 2017

1 reference

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SWI/SNF nucleosome remodellers and cancer.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

A conditional mouse model of synovial sarcoma: insights into a myogenic origin

2 October 2017

1 reference

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Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

A novel fusion gene, SYT-SSX4, in synovial sarcoma.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Characteristic chromosome abnormalities and karyotype profiles in soft tissue tumors.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X; 18)(p11.2;q11.2)-positive synoviaol sarcomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Cytogenetics of synovial sarcoma: presentation of ten new cases and review of the literature

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Morphological and cytogenetic studies of a human synovial sarcoma xenotransplanted into nude mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Establishment and characterization of a new human synovial sarcoma cell line, HS-SY-II

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

A unique pattern of INI1 immunohistochemistry distinguishes synovial sarcoma from its histologic mimics.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Reduced expression of SMARCB1/INI1 protein in synovial sarcoma.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Primary pulmonary and mediastinal synovial sarcoma: a clinicopathologic study of 60 cases and comparison with five prior series.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Poorly differentiated synovial sarcoma: immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4938529

Diagnosis of synovial sarcoma with the reverse transcriptase-polymerase chain reaction: analyses of 84 soft tissue and bone tumors

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27391784

12 December 2020

inferred from PubMed ID database lookup

Neural cell adhesion molecule distribution in soft tissue tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27391784

12 December 2020

inferred from PubMed ID database lookup

Ewing tumours and synovial sarcomas have critical features of karyotype evolution in common with epithelial tumours

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27391784

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PONE.0158888

1 reference

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

27391784

1 reference