Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL. (Q36140862)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26041884%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL (English)

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16 February 2020

6

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16 February 2020

Emanuela Rosati

10

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16 February 2020

author name string

Filomena De Falco

1

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16 February 2020

Rita Sabatini

2

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16 February 2020

Beatrice Del Papa

3

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16 February 2020

Franca Falzetti

4

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16 February 2020

Mauro Di Ianni

5

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16 February 2020

Stefano Baldoni

7

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16 February 2020

Isabella Screpanti

8

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16 February 2020

Pierfrancesco Marconi

9

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16 February 2020

language of work or name

English

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publication date

1 June 2015

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16 February 2020

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16 February 2020

volume

6

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16 February 2020

issue

18

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16 February 2020

page(s)

16559-16572

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Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells

16 February 2020

cites work

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2 October 2017

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2 October 2017

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

2 October 2017

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2 October 2017

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Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer

2 October 2017

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Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival

2 October 2017

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Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

2 October 2017

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Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.

2 October 2017

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Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

2 October 2017

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Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

2 October 2017

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Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab

2 October 2017

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mTORC1 promotes survival through translational control of Mcl-1.

2 October 2017

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Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches

2 October 2017

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The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

2 October 2017

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Unique biology of Mcl-1: therapeutic opportunities in cancer

2 October 2017

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2 October 2017

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2 October 2017

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The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

2 October 2017

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Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation

2 October 2017

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Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

2 October 2017

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Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation

2 October 2017

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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

2 October 2017

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Recent insights into the role of Notch signaling in tumorigenesis

2 October 2017

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Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway

2 October 2017

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2 October 2017

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

2 October 2017

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Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

2 October 2017

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

2 October 2017

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The γ-secretase inhibitor PF-03084014 combined with fludarabine antagonizes migration, invasion and angiogenesis in NOTCH1-mutated CLL cells

2 October 2017

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Pharmacological targeting of eIF4E in primary CLL lymphocytes

2 July 2018

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Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

2 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4599289

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2 July 2018

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A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia.

2 July 2018

1 reference

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Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.

23 September 2018

1 reference

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23 September 2018

1 reference

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c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells

23 September 2018

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23 September 2018

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23 September 2018

1 reference

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23 September 2018

1 reference

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Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

23 September 2018

1 reference

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23 September 2018

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NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

23 September 2018

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12 December 2020

Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

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12 December 2020

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

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12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.4116

1 reference

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16 February 2020

1 reference

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16 February 2020

PubMed publication ID

26041884

1 reference

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