Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain (Q36201884)

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English	Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain	scientific article

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6 February 2020

Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain (English)

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6 February 2020

Myles H. Akabas

2

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6 February 2020

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Moez Bali

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22 June 2012

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6 February 2020

Journal of Biological Chemistry

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6 February 2020

287

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6 February 2020

33

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6 February 2020

27762-27770

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6 February 2020

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

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1 October 2017

Accessing protein conformational ensembles using room-temperature X-ray crystallography

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1 October 2017

Principles of activation and permeation in an anion-selective Cys-loop receptor

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1 October 2017

Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.

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1 October 2017

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

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1 October 2017

GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

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1 October 2017

Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states

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Binding, activation and modulation of Cys-loop receptors.

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1 October 2017

Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors

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1 October 2017

GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site

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1 October 2017

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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1 October 2017

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

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1 October 2017

GABA A receptors: subtypes provide diversity of function and pharmacology

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1 October 2017

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

1 reference

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1 October 2017

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment

1 reference

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1 October 2017

The location of a closed channel gate in the GABAA receptor channel.

1 reference

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1 October 2017

Molecular targets underlying general anaesthesia

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1 October 2017

Probing ion-channel pores one proton at a time

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1 October 2017

A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.

1 reference

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1 October 2017

Emerging molecular mechanisms of general anesthetic action.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431678

1 October 2017

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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1 October 2017

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431678

1 October 2017

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

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1 October 2017

Coupling of agonist binding to channel gating in the GABA(A) receptor

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1 October 2017

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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1 October 2017

Constructing inhibitory synapses

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1 October 2017

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

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1 October 2017

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

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1 October 2017

Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore

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1 October 2017

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431678

1 October 2017

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

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1 October 2017

From ion currents to genomic analysis: recent advances in GABAA receptor research.

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1 October 2017

Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping

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1 October 2017

State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

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2 July 2018

Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment

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2 July 2018

Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor

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2 July 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the beta-subunit

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2 July 2018

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

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21 January 2018

Defining the propofol binding site location on the GABAA receptor

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21 January 2018

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.

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21 January 2018

Preservation and staining of myelinated nerve fibers

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21 January 2018

Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments

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21 January 2018

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

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21 January 2018

Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.

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21 January 2018

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit

1 reference

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21 January 2018

Lipid composition alters drug action at the nicotinic acetylcholine receptor.

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21 January 2018

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

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based on heuristic

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10.1074/JBC.M112.363341

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6 February 2020

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6 February 2020

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6 February 2020

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