Histone deacetylase inhibitors: insights into mechanisms of lethality (Q36219726)

12 August 2017

1 reference

title

Histone deacetylase inhibitors: insights into mechanisms of lethality (English)

1 reference

12 August 2017

Roberto R Rosato

1

1 reference

PubMed ID

16083344

12 August 2017

Steven Grant

series ordinal

2

1 reference

PubMed ID

16083344

12 August 2017

language of work or name

English

0 references

publication date

1 August 2005

1 reference

Expert Opinion on Therapeutic Targets

12 August 2017

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12 August 2017

9

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12 August 2017

4

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12 August 2017

809-824

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STI571 as a targeted therapy for CML.

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone modifications as key regulators of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone acetylation and chromatin remodeling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors: understanding a new wave of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Clinical development of histone deacetylase inhibitors as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Sodium butyrate inhibits histone deacetylation in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Novel mutual prodrug of retinoic and butyric acids with enhanced anticancer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Valproic acid treatment of glioblastoma multiforme in a child

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors: from target to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Chronic oral administration of CI-994: a phase 1 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Preclinical antitumor activity of CI-994.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Induction of Apoptosis in Rat Peripheral Blood Lymphocytes by the Anticancer Drug CI-994 (Acetyldinaline)(*).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

A phase I study of the oral combination of CI-994, a putative histone deacetylase inhibitor, and capecitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Phase I study of oral CI-994 in combination with gemcitabine in treatment of patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Enhancement of xenograft tumor radiosensitivity by the histone deacetylase inhibitor MS-275 and correlation with histone hyperacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylases and cancer: causes and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitor enhances the anti-leukemic activity of an established nucleoside analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylases as therapeutic targets in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Epigenetics in human disease and prospects for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The human histone deacetylase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The Sir2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Class II histone deacetylases: from sequence to function, regulation, and clinical implication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Yeast life-span extension by calorie restriction is independent of NAD fluctuation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Calorie restriction, SIRT1 and metabolism: understanding longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Calorie restriction--the SIR2 connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Reactivating the expression of methylation silenced genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Worms gang up on bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Frequent mutations in the ligand-binding domain of PML-RARalpha after multiple relapses of acute promyelocytic leukemia: analysis for functional relationship to response to all-trans retinoic acid and histone deacetylase inhibitors in vitro and in v

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Reactive oxygen species in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Regulation and measurement of oxidative stress in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Redox regulation and signaling lipids in mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Properties and biological activities of thioredoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Glutathione in defense and signaling: lessons from a small thiol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Physiological functions of thioredoxin and thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Molecular pathogenesis of acute promyelocytic leukaemia and APL variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Shaping the nuclear action of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The TRAIL to selective tumor death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Biologically active sphingolipids in cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Glycosphingolipids and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Interleukin-1beta converting enzyme subfamily inhibitors prevent induction of CD86 molecules by butyrate through a CREB-dependent mechanism in HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Butyrate suppression of colonocyte NF-kappa B activation and cellular proteasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Sphingosine-1-phosphate: dual messenger functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Generation and metabolism of bioactive sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Regulation of ceramide production and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Heat-shock proteins as regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Heat shock proteins--modulators of apoptosis in tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Hsp90: an emerging target for breast cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

HDAC6 is a microtubule-associated deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.4.809

Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

21 January 2018

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1128/JVI.78.9.4582-4590.2004

Identifiers

DOI

10.1517/14728222.9.4.809

1 reference

12 August 2017

1 reference

PubMed ID

16083344