RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation (Q36245598)

13 August 2017

RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation (English)

1 reference

13 August 2017

Ying Yan

1

1 reference

13 August 2017

Patrick M Greer

2

1 reference

13 August 2017

Phu T Cao

3

1 reference

13 August 2017

Ryan H Kolb

4

1 reference

13 August 2017

Kenneth H Cowan

5

1 reference

13 August 2017

11 April 2012

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13 August 2017

Breast Cancer Research

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13 August 2017

14

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13 August 2017

2

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13 August 2017

R60

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3446395/fullTextXML

inferred from PubMed Central ID database lookup

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Understanding the limitations of radiation-induced cell cycle checkpoints

1 October 2017

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Telomerase-immortalized human mammary stem/progenitor cells with ability to self-renew and differentiate

1 October 2017

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Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein

1 October 2017

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The G(2) DNA damage checkpoint: could this ancient regulator be the Achilles heel of cancer?

1 October 2017

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

1 October 2017

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Rac1 GTPase: a "Rac" of all trades.

1 October 2017

1 reference

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Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

1 October 2017

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Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy

1 October 2017

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Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

1 October 2017

1 reference

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Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells

1 October 2017

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p53 and breast cancer, an update

1 October 2017

1 reference

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The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

1 October 2017

1 reference

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The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage

1 October 2017

1 reference

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Cell-cycle checkpoints and cancer

1 October 2017

1 reference

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

1 October 2017

1 reference

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

1 October 2017

1 reference

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DNA damage tumor suppressor genes and genomic instability

1 October 2017

1 reference

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G2 checkpoint abrogators as anticancer drugs

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

MAPK pathways in radiation responses

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

DNA damage checkpoint control in cells exposed to ionizing radiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Phosphorylation of serine 10 in histone H3, what for?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Checking out the G(2)/M transition.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Regulation of the G2/M transition by p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal--regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Phosphorylation-induced rearrangement of the histone H3 NH2-terminal domain during mitotic chromosome condensation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Rac1 is required for cell proliferation and G2/M progression.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Analyzing cell cycle checkpoints after ionizing radiation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Rho GTPases are over-expressed in human tumors.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3446395

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FBCR3164

p27Kip1 overexpression causes apoptotic death of mammalian cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22494620

12 December 2020

inferred from PubMed ID database lookup

BRCA1-induced apoptosis involves inactivation of ERK1/2 activities

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22494620

12 December 2020

inferred from PubMed ID database lookup

Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22494620

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1186/BCR3164

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

22494620

1 reference