The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes (Q36266503)

13 August 2017

The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes (English)

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13 August 2017

Christopher A Lazarski

7

object named as

Christopher A Lazarski

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13 August 2017

Andrea J Sant

1

1 reference

13 August 2017

Francisco A Chaves

2

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13 August 2017

Scott A Jenks

3

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13 August 2017

Katherine A Richards

4

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13 August 2017

Paula Menges

5

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13 August 2017

J M Weaver

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13 August 2017

1 October 2005

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13 August 2017

Immunological Reviews

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13 August 2017

207

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13 August 2017

261-278

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Reversal of immunodominance among autoantigenic T-cell epitopes

13 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Modulation of the immunogenicity of antigenic determinants by their flanking residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Antigen processing and T cell repertoires as crucial aleatory features in induction of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Epitope dominance, competition and T cell affinity maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Tracking antigen-specific helper T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

How HLA-DM affects the peptide repertoire bound to HLA-DR molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Nonclassical MHC class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Developing and shedding inhibitions: how MHC class II molecules reach maturity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Mediation by HLA-DM of dissociation of peptides from HLA-DR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Structural factors contributing to DM susceptibility of MHC class II/peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Quality control of MHC class II associated peptides by HLA-DM/H2-M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Second class minors: molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by major histocompatibility complex class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Cutting edge: editing of recycling class II:peptide complexes by HLA-DM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

DM determines the cryptic and immunodominant fate of T cell epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Naturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

In vivo activation of antigen-specific CD4 T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Visualization of specific B and T lymphocyte interactions in the lymph node.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Structural and functional consequences of altering a peptide MHC anchor residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Modification of peptide interaction with MHC creates TCR partial agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The magnitude of TCR engagement is a critical predictor of T cell anergy or activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T cells compete for access to antigen-bearing antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Competition for antigenic sites during T cell proliferation: a mathematical interpretation of in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Antigen presentation and T cell stimulation by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Dendritic cells and the control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Antigen presentation to naive CD4 T cells in the lymph node.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Progressive differentiation and selection of the fittest in the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Antigen decoding by T lymphocytes: from synapses to fate determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The duration of antigenic stimulation determines the fate of naive and effector T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Self-representation in the thymus: an extended view

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Regulating self-tolerance by deregulating gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Good riddance: Thymocyte clonal deletion prevents autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Low-avidity recognition by CD4+ T cells directed to self-antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Endogenous myelin basic protein inactivates the high avidity T cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Autoimmunity in the central nervous system: mechanisms of antigen presentation and recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T cell receptor antagonist peptides induce positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Structural basis for helper T-cell and antibody epitope immunodominance in bacteriophage T4 Hsp10. Role of disordered loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Antigen processing in the endocytic compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Lysosomal cysteine proteases regulate antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

A closer look at proteolysis and MHC-class-II-restricted antigen presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

The lysosomal cysteine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

Epitope-based vaccines: an update on epitope identification, vaccine design and delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

In vivo competition between self peptides and foreign antigens in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2005.00307.X

10.1111/J.0105-2896.2005.00307.X

21 January 2018

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DOI

1 reference

13 August 2017

1 reference