Apoptosis and necrosis in the liver: a tale of two deaths? (Q36382247)

13 August 2017

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title

Apoptosis and necrosis in the liver: a tale of two deaths? (English)

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13 August 2017

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2

Gregory J Gores

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13 August 2017

Harmeet Malhi

1

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13 August 2017

John J Lemasters

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 February 2006

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13 August 2017

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13 August 2017

volume

43

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13 August 2017

issue

2 Suppl 1

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13 August 2017

page(s)

S31-44

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

13 August 2017

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The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release

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Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis

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Centrilobular injury following hypoxia in isolated, perfused rat liver

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7 January 2021

Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver

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7 January 2021

Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury

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7 January 2021

Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine

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Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death

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7 January 2021

Calcium dependence of bleb formation and cell death in hepatocytes

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Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia

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Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules

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The nature of piecemeal necrosis in chronic active hepatitis

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Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury.

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7 January 2021

Apoptosis: overview and signal transduction pathways

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The pathophysiology of mitochondrial cell death

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7 January 2021

Cytochrome C-mediated apoptosis

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c.

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7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

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7 January 2021

Mitochondrial permeability transition is a central coordinating event of apoptosis

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7 January 2021

The Mitochondrial Permeability Transition Augments Fas-induced Apoptosis in Mouse Hepatocytes

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7 January 2021

Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

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7 January 2021

Cyclophilin D as a drug target

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7 January 2021

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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7 January 2021

Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?

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7 January 2021

Mechanisms by which mitochondria transport calcium

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7 January 2021

The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187.

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7 January 2021

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes

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7 January 2021

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury

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7 January 2021

Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes.

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7 January 2021

Inhibition of Na+/H+ exchange preserves viability, restores mechanical function, and prevents the pH paradox in reperfusion injury to rat neonatal myocytes

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7 January 2021

Intracellular pH and Ca2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes

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7 January 2021

Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?

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7 January 2021

Evaluation of the electroinjection method for introducing proteins into living cells

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7 January 2021

Mechanisms of hepatotoxicity

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7 January 2021

CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver

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7 January 2021

Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion

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7 January 2021

Reperfusion injury to endothelial cells following cold ischemic storage of rat livers

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7 January 2021

Sinusoidal endothelial cell and hepatocyte death following cold ischemia-warm reperfusion of the rat liver.

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7 January 2021

Reperfusion injury after liver preservation for transplantation

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7 January 2021

Protection by Carolina rinse solution, acidotic pH, and glycine against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation

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7 January 2021

Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival

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7 January 2021

Apoptosis after ischemia-reperfusion in human liver allografts

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7 January 2021

Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation

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7 January 2021

Viability of liver grafts from fasted donor rats: relationship to sinusoidal endothelial cell apoptosis

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7 January 2021

"Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with In situ nick end-labeling

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7 January 2021

The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury

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7 January 2021

Expression of BCL-2 in liver grafts after adenoviral transfer improves survival following prolonged ischemia and reperfusion in rat liver transplantation

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7 January 2021

Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver

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7 January 2021

Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice

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7 January 2021

Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection

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7 January 2021

Expression of bcl-2 inhibits necrotic neural cell death.

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7 January 2021

Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

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7 January 2021

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

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7 January 2021

Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition

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7 January 2021

Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes

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7 January 2021

RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant.

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7 January 2021

IAP proteins: blocking the road to death's door

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7 January 2021

Mammalian mitochondrial IAP binding proteins

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7 January 2021

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

1 reference

7 January 2021

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

1 reference

7 January 2021

The CD95(APO-1/Fas) DISC and beyond

1 reference

7 January 2021

The TNF receptor 1: a split personality complex

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7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

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7 January 2021

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis

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7 January 2021

Fas-mediated apoptosis in primary cultured mouse hepatocytes

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7 January 2021

Fas-mediated cholangiopathy in the murine model of graft versus host disease

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7 January 2021

Fas (CD95, APO-1) antigen expression and function in murine liver endothelial cells: implications for the regulation of apoptosis in liver endothelial cells.

1 reference

7 January 2021

Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells

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7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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7 January 2021

Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.

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7 January 2021

The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.

1 reference

7 January 2021

Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis

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7 January 2021

Involvement of the Src family kinase yes in bile salt-induced apoptosis

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7 January 2021

The CTL's kiss of death

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7 January 2021

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

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7 January 2021

Variations in the serum concentrations of soluble Fas and soluble Fas ligand in Vietnamese patients infected with hepatitis B virus

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7 January 2021

Induction of hepatic injury by hepatitis C virus-specific CD8+ murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes

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7 January 2021

Essential roles of the Fas ligand in the development of hepatitis

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7 January 2021

Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection

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7 January 2021

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

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7 January 2021

Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure

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7 January 2021

Cytochrome c is a possible new marker for fulminant hepatitis in humans

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7 January 2021

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

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7 January 2021

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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7 January 2021

Hepatic expression of type A and type B receptors for tumor necrosis factor

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7 January 2021

Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor

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7 January 2021

Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

1 reference

7 January 2021

Increased plasma tumor necrosis factor in severe alcoholic hepatitis

1 reference

7 January 2021

Soluble TNF-R1, but not tumor necrosis factor alpha, predicts the 3-month mortality in patients with alcoholic hepatitis

1 reference

7 January 2021

Kinetics of soluble tumour necrosis factor (TNF)-alpha receptors and cytokines in the early phase of treatment for chronic hepatitis C: comparison between interferon (IFN)-alpha alone, IFN-alpha plus amantadine or plus ribavirin

1 reference

7 January 2021

Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver

1 reference

7 January 2021

Death Receptor Activation-Induced Hepatocyte Apoptosis and Liver Injury

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7 January 2021

NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis

1 reference

7 January 2021

Lethal effect of the anti-Fas antibody in mice

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7 January 2021

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1 reference

7 January 2021

Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection

1 reference

7 January 2021

Cytokine regulation of liver injury and repair

1 reference

7 January 2021

Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells

1 reference

7 January 2021

Potentiation of antimetabolite action by uridylate trapping

1 reference

7 January 2021

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice

1 reference

7 January 2021

c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation

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7 January 2021

JNK mediates hepatic ischemia reperfusion injury

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7 January 2021

Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2

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7 January 2021

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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7 January 2021

Critical roles of TRAIL in hepatic cell death and hepatic inflammation.

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7 January 2021

Involvement of TRAIL and its receptors in viral hepatitis

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7 January 2021

TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice

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7 January 2021

Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

1 reference

7 January 2021

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

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7 January 2021

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

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7 January 2021

Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease

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7 January 2021

Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

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7 January 2021

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

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7 January 2021

Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis.

1 reference

7 January 2021

Bile salt-induced apoptosis involves NADPH oxidase isoform activation

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7 January 2021

Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.

1 reference

7 January 2021

The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse

1 reference

7 January 2021

Oncosis represents the main type of cell death in mouse models of cholestasis

1 reference

7 January 2021

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

1 reference

7 January 2021

Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients

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7 January 2021

Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice

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7 January 2021

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

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7 January 2021

NASH: a mitochondrial disease

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7 January 2021

Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.

1 reference

7 January 2021

Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure

1 reference

7 January 2021

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

1 reference

7 January 2021

Selective protein arylation and acetaminophen-induced hepatotoxicity

1 reference

7 January 2021

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

1 reference

7 January 2021

Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases

1 reference

7 January 2021

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

1 reference

7 January 2021

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

7 January 2021

VDAC2 inhibits BAK activation and mitochondrial apoptosis

1 reference

7 January 2021

Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

1 reference

7 January 2021

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

1 reference

7 January 2021

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

1 reference

7 January 2021

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection

1 reference

7 January 2021

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.

1 reference

7 January 2021

Caspase 8 small interfering RNA prevents acute liver failure in mice

1 reference

7 January 2021

Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-alpha production by Kupffer cells

1 reference

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

7 January 2021

Fas siRNA reduces apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen

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7 January 2021

Developing strategies for liver fibrosis treatment

1 reference

7 January 2021

Gliotoxin-mediated apoptosis of activated human hepatic stellate cells

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7 January 2021

1 reference

7 January 2021

A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome

1 reference

7 January 2021

The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis

1 reference

7 January 2021

Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications

1 reference

7 January 2021

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

1 reference

7 January 2021

Targeted treatments for cirrhosis

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7 January 2021

Identifiers

DOI

10.1002/HEP.21062

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13 August 2017

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