Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). (Q36473477)

14 August 2017

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title

Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). (English)

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14 August 2017

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2

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14 August 2017

Thomas K H Chang

1

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14 August 2017

language of work or name

English

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publication date

1 January 2006

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14 August 2017

published in

Drug Metabolism Reviews

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14 August 2017

volume

38

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14 August 2017

issue

1-2

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14 August 2017

page(s)

51-73

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

14 August 2017

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Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

21 January 2018

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Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

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Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse

21 January 2018

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Structure and function of the human nuclear xenobiotic receptor PXR.

21 January 2018

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Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

21 January 2018

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Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor

21 January 2018

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Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

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Interactions between antiepileptic drugs and hormonal contraception

21 January 2018

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Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

21 January 2018

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Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

21 January 2018

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The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter

21 January 2018

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Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

21 January 2018

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

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Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

21 January 2018

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Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

21 January 2018

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Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients

21 January 2018

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

21 January 2018

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Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

21 January 2018

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Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

21 January 2018

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CAR: detailing new models

21 January 2018

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Enhanced acetaminophen toxicity by activation of the pregnane X receptor

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

21 January 2018

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Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital

21 January 2018

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A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

21 January 2018

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Pharmacokinetic enhancement of protease inhibitor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Regulation of hepatic transporters by xenobiotic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Qinghaosu (artemisinin): an antimalarial drug from China

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

CAR and PXR: xenosensors of endocrine disrupters?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Loss of detoxification in inflammatory bowel disease: dysregulation of pregnane X receptor target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Dual action of oestrogens on the mouse constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Nuclear receptors as targets for drug development: regulation of cholesterol and bile acid metabolism by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Upregulation of cytochromes P450 2B in rat liver by orphenadrine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Pathophysiological factors affecting CAR gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

CAR, the continuously advancing receptor, in drug metabolism and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Induction of PXR-mediated metabolism by beta-carotene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Vitamin E, nuclear receptors and xenobiotic metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

Complex effects of rexinoids on ligand dependent activation or inhibition of the xenobiotic receptor, CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Role reversal: new insights from new ligands for the xenobiotic receptor CAR.

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530600569828

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Chronic ethanol exposure downregulates hepatic expression of pregnane X receptor and P450 3A11 in female ICR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Phenobarbital induction of cytochrome P-450 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

St John's wort, a herbal antidepressant, activates the steroid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

PXR, CAR and drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Selected ion monitoring assay for meclizine in human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Artemisinin induces omeprazole metabolism in human beings

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

Simultaneous determination of the stereoisomers of guggulsterone in serum by high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600569828

10.1080/03602530600569828

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference