BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes (Q36478810)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702098%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes (English)

1 reference

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3 March 2020

3

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3 March 2020

Chenyi Liao

4

1 reference

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3 March 2020

Samson G F Condon

7

1 reference

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3 March 2020

Feng He

11

1 reference

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3 March 2020

Alessandro Senes

14

1 reference

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3 March 2020

David William Andrews

15

1 reference

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3 March 2020

author name string

Zhi Zhang

1

1 reference

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3 March 2020

Sabareesh Subramaniam

2

1 reference

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3 March 2020

Bo Huang

5

1 reference

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3 March 2020

Hetal Brahmbhatt

6

1 reference

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3 March 2020

Suzanne M Lapolla

8

1 reference

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3 March 2020

Franklin A Hays

9

1 reference

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3 March 2020

Jingzhen Ding

10

1 reference

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3 March 2020

Xuejun C Zhang

12

1 reference

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3 March 2020

Jianing Li

13

1 reference

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3 March 2020

Jialing Lin

16

1 reference

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3 March 2020

language of work or name

English

0 references

publication date

23 December 2015

1 reference

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3 March 2020

1 reference

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3 March 2020

volume

35

1 reference

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3 March 2020

issue

2

1 reference

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3 March 2020

page(s)

208-236

1 reference

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Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond

3 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Differential retrotranslocation of mitochondrial Bax and Bak.

30 September 2017

1 reference

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Conformational rearrangements in the pro-apoptotic protein, Bax, as it inserts into mitochondria: a cellular death switch

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Backbone dependency further improves side chain prediction efficiency in the Energy-based Conformer Library (bEBL).

30 September 2017

1 reference

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Regulating cell death at, on, and in membranes.

30 September 2017

1 reference

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

30 September 2017

1 reference

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After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

30 September 2017

1 reference

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A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical Cα-H hydrogen bonds.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Many players in BCL-2 family affairs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

30 September 2017

1 reference

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Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

The rheostat in the membrane: BCL-2 family proteins and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

tBid undergoes multiple conformational changes at the membrane required for Bax activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structural Organization of FtsB, a Transmembrane Protein of the Bacterial Divisome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

The secrets of the Bcl-2 family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

An energy-based conformer library for side chain optimization: improved prediction and adjustable sampling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structural informatics, modeling, and design with an open-source Molecular Software Library (MSL).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bax forms an oligomer via separate, yet interdependent, surfaces

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Improved prediction of protein side-chain conformations with SCWRL4

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structural basis for dimerization of the BNIP3 transmembrane domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bcl-XL inhibits membrane permeabilization by competing with Bax.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Helix-packing motifs in membrane proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Remarkably high activities of testicular cytochrome c in destroying reactive oxygen species and in triggering apoptosis

30 September 2017

1 reference

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Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

30 September 2017

1 reference

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

30 September 2017

1 reference

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

30 September 2017

1 reference

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Extending the accuracy limits of prediction for side-chain conformations

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structure of Bax: coregulation of dimer formation and intracellular localization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

30 September 2017

1 reference

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The GxxxG motif: a framework for transmembrane helix-helix association

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

A transmembrane helix dimer: structure and implications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Crystal structure of the Aequorea victoria green fluorescent protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Structural model of active Bax at the membrane.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

The apoptotic pore on mitochondria: are we breaking through or still stuck?

28 June 2018

1 reference

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Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Transmembrane pore formation by the carboxyl terminus of Bax protein

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

28 June 2018

1 reference

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Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Molecular details of Bax activation, oligomerization, and membrane insertion.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4718459

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26702098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/26702098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26702098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201591552

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702098%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26702098%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference