Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. (Q36512589)

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scientific article published on 17 April 2012

Language	Label	Description	Also known as
English	Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.	scientific article published on 17 April 2012

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. (English)

1 reference

Europe PubMed Central

14 August 2017

1 reference

based on heuristic

inferred from title

Edward Rockenstein

5

object named as

Edward Rockenstein

1 reference

Europe PubMed Central

14 August 2017

Eliezer Masliah

8

object named as

Eliezer Masliah

1 reference

Europe PubMed Central

14 August 2017

author name string

Brian Spencer

1

1 reference

Europe PubMed Central

14 August 2017

Sarah Michael

2

1 reference

Europe PubMed Central

14 August 2017

Jay Shen

3

1 reference

Europe PubMed Central

14 August 2017

Kori Kosberg

4

1 reference

Europe PubMed Central

14 August 2017

Christina Patrick

6

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Europe PubMed Central

14 August 2017

Anthony Adame

7

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Europe PubMed Central

14 August 2017

publication date

17 April 2012

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Europe PubMed Central

14 August 2017

Molecular Therapy

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Europe PubMed Central

14 August 2017

21

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14 August 2017

1

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Europe PubMed Central

14 August 2017

31-41

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Europe PubMed Central

14 August 2017

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease

1 reference

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A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

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Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis

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Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease

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Novel strategies for Alzheimer's disease treatment

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The autolytic regulation of human kallikrein-related peptidase 6.

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

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Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

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Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies

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Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

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The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry

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alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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The role of synaptic proteins in Alzheimer's disease

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Pathoanatomy of Parkinson's disease

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Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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30 September 2017

Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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30 September 2017

Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3538325

30 September 2017

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

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28 June 2018

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

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Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

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28 June 2018

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

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28 June 2018

Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia

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21 September 2018

Extracellular neurosin degrades α-synuclein in cultured cells.

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21 September 2018

Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.

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Exogenous kallikrein enhances neurogenesis and angiogenesis in the subventricular zone and the peri-infarction region and improves neurological function after focal cortical infarction in hypertensive rats

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Production and purification of lentiviral vectors

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Lipid rafts mediate the synaptic localization of alpha-synuclein.

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Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

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Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.

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Protease M/neurosin mRNA is expressed in mature oligodendrocytes.

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Neuropathology of Alzheimer's disease: a critical update.

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Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment

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Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22508489

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MT.2012.66

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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