Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc (Q36535153)

14 August 2017

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc (English)

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14 August 2017

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16

Peter P Nawroth

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14 August 2017

Fabian Bock

1

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14 August 2017

Khurrum Shahzad

2

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14 August 2017

Hongjie Wang

3

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14 August 2017

Stoyan Stoyanov

4

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14 August 2017

Juliane Wolter

5

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14 August 2017

Wei Dong

6

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14 August 2017

Pier Giuseppe Pelicci

7

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14 August 2017

Muhammed Kashif

8

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14 August 2017

Satish Ranjan

9

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14 August 2017

Simone Schmidt

10

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14 August 2017

Robert Ritzel

11

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14 August 2017

Vedat Schwenger

12

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14 August 2017

Klaus G Reymann

13

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14 August 2017

Charles T Esmon

14

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14 August 2017

Thati Madhusudhan

15

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14 August 2017

Berend Isermann

17

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14 August 2017

language of work or name

English

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publication date

24 December 2012

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Proceedings of the National Academy of Sciences of the United States of America

14 August 2017

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14 August 2017

110

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14 August 2017

2

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14 August 2017

648-653

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Protein C anticoagulant and cytoprotective pathways

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Bioenergetic characterization of mouse podocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

30 September 2017

P66Shc signals to age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Oxidative stress as a major culprit in kidney disease in diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Biochemistry and molecular cell biology of diabetic complications

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Deletion of the ageing gene p66(Shc) reduces early stroke size following ischaemia/reperfusion brain injury

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3545757

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1218667110

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23267072

12 December 2020

inferred from PubMed ID database lookup

Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23267072

12 December 2020

inferred from PubMed ID database lookup

Exogenous activated protein C inhibits the progression of diabetic nephropathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23267072

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1218667110

1 reference

release_7yu5jxj4cvfi7modop2nywt2va

14 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7yu5jxj4cvfi7modop2nywt2va

24 November 2022

mapped directly with Wikidata item

1 reference

14 August 2017

1 reference