Expressing short hairpin RNAs in vivo (Q36575396)

15 August 2017

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title

Expressing short hairpin RNAs in vivo (English)

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15 August 2017

Ola Snøve

1

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PubMed ID

16929313

15 August 2017

John J Rossi

series ordinal

2

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15 August 2017

1 September 2006

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15 August 2017

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15 August 2017

3

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15 August 2017

689-695

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15 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nmeth927

15 August 2017

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cites work

On the art of identifying effective and specific siRNAs

1 reference

7 January 2021

Enhancing and confirming the specificity of RNAi experiments

1 reference

7 January 2021

Progress towards in vivo use of siRNAs

1 reference

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

7 January 2021

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

1 reference

7 January 2021

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

1 reference

7 January 2021

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

7 January 2021

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

1 reference

7 January 2021

RNAi-mediated gene silencing in non-human primates.

1 reference

7 January 2021

Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model

1 reference

7 January 2021

Delivery of siRNA and siRNA expression constructs to adult mammals by hydrodynamic intravascular injection

1 reference

7 January 2021

Hydroporation as the mechanism of hydrodynamic delivery

1 reference

7 January 2021

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

1 reference

7 January 2021

Functional silencing of hepatic microsomal glucose-6-phosphatase gene expression in vivo by adenovirus-mediated delivery of short hairpin RNA.

1 reference

7 January 2021

Adenovirus-mediated silencing of huntingtin expression by shRNA.

1 reference

7 January 2021

Gene disruption by regulated short interfering RNA expression, using a two-adenovirus system.

1 reference

7 January 2021

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

1 reference

7 January 2021

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo

1 reference

7 January 2021

Progress and problems with the use of viral vectors for gene therapy

1 reference

7 January 2021

Improving erectile function by silencing phosphodiesterase-5.

1 reference

7 January 2021

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

1 reference

7 January 2021

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

1 reference

7 January 2021

Current development of lentiviral-mediated gene transfer

1 reference

7 January 2021

Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system

1 reference

7 January 2021

Altering the tropism of lentiviral vectors through pseudotyping

1 reference

7 January 2021

Identification of novel genes coding for small expressed RNAs

1 reference

7 January 2021

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

1 reference

7 January 2021

An extensive class of small RNAs in Caenorhabditis elegans

1 reference

7 January 2021

Role for a bidentate ribonuclease in the initiation step of RNA interference

1 reference

7 January 2021

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

7 January 2021

siRNAs can function as miRNAs

1 reference

7 January 2021

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

1 reference

7 January 2021

A microRNA in a multiple-turnover RNAi enzyme complex

1 reference

7 January 2021

MicroRNA-directed cleavage of HOXB8 mRNA

1 reference

7 January 2021

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

1 reference

7 January 2021

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

1 reference

7 January 2021

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

1 reference

7 January 2021

MicroRNAs regulate brain morphogenesis in zebrafish

1 reference

7 January 2021

MicroRNAs direct rapid deadenylation of mRNA

1 reference

7 January 2021

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

1 reference

7 January 2021

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

1 reference

7 January 2021

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1 reference

7 January 2021

Towards safe, non-viral therapeutic gene expression in humans.

1 reference

7 January 2021

DNA-based therapeutics and DNA delivery systems: a comprehensive review

1 reference

7 January 2021

Activation of the interferon system by short-interfering RNAs

1 reference

7 January 2021

Induction of an interferon response by RNAi vectors in mammalian cells

1 reference

7 January 2021

Interactions between double-stranded RNA regulators and the protein kinase DAI

1 reference

7 January 2021

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

1 reference

7 January 2021

Activation of the mammalian immune system by siRNAs.

1 reference

7 January 2021

Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs

1 reference

7 January 2021

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

1 reference

7 January 2021

Nuclear export of microRNA precursors

1 reference

7 January 2021

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

1 reference

7 January 2021

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

7 January 2021

The Microprocessor complex mediates the genesis of microRNAs

1 reference

7 January 2021

The Drosha-DGCR8 complex in primary microRNA processing

1 reference

7 January 2021

The nuclear RNase III Drosha initiates microRNA processing

1 reference

7 January 2021

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

1 reference

7 January 2021

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

1 reference

7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

7 January 2021

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

7 January 2021

Rational siRNA design for RNA interference

1 reference

7 January 2021

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

1 reference

7 January 2021

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

1 reference

7 January 2021

Short 5'-phosphorylated double-stranded RNAs induce RNA interference in Drosophila.

1 reference

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

7 January 2021

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

7 January 2021

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

1 reference

7 January 2021

Expression profiling reveals off-target gene regulation by RNAi

1 reference

7 January 2021

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

7 January 2021

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

1 reference

7 January 2021

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

1 reference

7 January 2021

RISC is a 5' phosphomonoester-producing RNA endonuclease

1 reference

7 January 2021

Kinetic analysis of the RNAi enzyme complex

1 reference

7 January 2021

Micromanagement: a role for microRNAs in mRNA stability

1 reference

7 January 2021

Principles of microRNA-target recognition

1 reference

7 January 2021

microRNA target predictions across seven Drosophila species and comparison to mammalian targets

1 reference

7 January 2021

Human MicroRNA targets

1 reference

7 January 2021

Prediction of mammalian microRNA targets

1 reference

7 January 2021

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

1 reference

7 January 2021

Combinatorial microRNA target predictions

1 reference

7 January 2021

Off-target effects by siRNA can induce toxic phenotype

1 reference

7 January 2021

Unlocking the potential of the human genome with RNA interference

1 reference

7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

1 reference

7 January 2021

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

1 reference

7 January 2021

Gene silencing using micro-RNA designed hairpins

1 reference

7 January 2021

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

1 reference

7 January 2021

Conserved microRNA characteristics in mammals.

1 reference

7 January 2021

A new vector, based on the PolII promoter of the U1 snRNA gene, for the expression of siRNAs in mammalian cells

1 reference

7 January 2021

A versatile tool for conditional gene expression and knockdown

1 reference

7 January 2021

Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA.

1 reference

7 January 2021

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

1 reference

7 January 2021

MicroRNA genes are transcribed by RNA polymerase II

1 reference

7 January 2021

Approaches for chemically synthesized siRNA and vector-mediated RNAi

1 reference

7 January 2021

Inducible, reversible, and stable RNA interference in mammalian cells

1 reference

7 January 2021

Transcriptional activation by tetracyclines in mammalian cells

1 reference

7 January 2021

Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

1 reference

7 January 2021

Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil

1 reference

7 January 2021

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor

1 reference

7 January 2021

Inducible shRNA expression for application in a prostate cancer mouse model

1 reference

7 January 2021

Inducible H1 promoter-driven lentiviral siRNA expression by Stuffer reporter deletion

1 reference

7 January 2021

Development of a tightly regulated U6 promoter for shRNA expression

1 reference

7 January 2021

Conditional inhibition of cancer cell proliferation by tetracycline-responsive, H1 promoter-driven silencing of PLK1.

1 reference

7 January 2021

Tuning silence: conditional systems for RNA interference

1 reference

7 January 2021

Lentiviral delivery of RNAi in hippocampal neurons.

1 reference

7 January 2021

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

1 reference

7 January 2021

Lentiviral vector delivery of recombinant small interfering RNA expression cassettes

1 reference

7 January 2021

Identifiers

DOI

10.1038/NMETH927

1 reference

15 August 2017

1 reference

PubMed ID

16929313