mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice (Q36580462)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23321674%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice (English)

1 reference

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22 February 2020

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11

1 reference

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22 February 2020

Fred Schaper

13

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22 February 2020

Alex Boussioutas

15

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22 February 2020

Matthias Ernst

18

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22 February 2020

14

Michael Hallek

1 reference

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22 February 2020

author name string

Stefan Thiem

1

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22 February 2020

Thomas P Pierce

2

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22 February 2020

Michelle Palmieri

3

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22 February 2020

Tracy L Putoczki

4

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22 February 2020

Michael Buchert

5

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22 February 2020

Adele Preaudet

6

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22 February 2020

Ryan O Farid

7

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22 February 2020

Chris Love

8

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22 February 2020

Bruno Catimel

9

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22 February 2020

Zhengdeng Lei

10

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22 February 2020

Veena Gopalakrishnan

12

1 reference

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22 February 2020

Patrick Tan

16

1 reference

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22 February 2020

Andrew Jarnicki

17

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22 February 2020

language of work or name

English

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publication date

16 January 2013

1 reference

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Journal of Clinical Investigation

22 February 2020

published in

1 reference

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22 February 2020

volume

123

1 reference

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22 February 2020

issue

2

1 reference

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22 February 2020

page(s)

767-781

1 reference

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

22 February 2020

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Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.

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More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer.

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Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?

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The emerging mechanisms of isoform-specific PI3K signalling

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Airway PI3K pathway activation is an early and reversible event in lung cancer development

9 September 2017

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Immunity, Inflammation, and Cancer

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Multicenter phase II study of everolimus in patients with previously treated metastatic gastric cancer

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Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: a review

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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression

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A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

9 September 2017

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Oncogenic pathway combinations predict clinical prognosis in gastric cancer.

9 September 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

9 September 2017

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

9 September 2017

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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

9 September 2017

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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

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STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

9 September 2017

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Mining for JAK-STAT mutations in cancer

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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

9 September 2017

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Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies

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Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

9 September 2017

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Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

9 September 2017

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Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

9 September 2017

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Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR

9 September 2017

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Ulcerative colitis and colorectal cancer. A population-based study

9 September 2017

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Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy

9 September 2017

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Exploring the specificity of the PI3K family inhibitor LY294002.

30 September 2017

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Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

30 September 2017

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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

30 September 2017

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

30 September 2017

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STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

30 September 2017

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

30 September 2017

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Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

20 September 2018

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

20 September 2018

1 reference

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Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

20 September 2018

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20 September 2018

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High resolution colonoscopy in live mice

20 September 2018

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12 December 2020

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12 December 2020

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

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12 December 2020

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12 December 2020

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12 December 2020

Cancer risk in patients with inflammatory bowel disease: a population-based study

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A bioactive designer cytokine for human hematopoietic progenitor cell expansion

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Identifiers

DOI

10.1172/JCI65086

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23321674%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23321674%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference