Therapeutic targets in the mitochondrial apoptotic pathway (Q36764882)

16 August 2017

1 reference

title

Therapeutic targets in the mitochondrial apoptotic pathway (English)

1 reference

16 August 2017

0 references

Georg Häcker

1

1 reference

PubMed ID

17373881

16 August 2017

Stefan A Paschen

series ordinal

2

1 reference

PubMed ID

17373881

16 August 2017

language of work or name

English

0 references

publication date

1 April 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

1 reference

16 August 2017

11

1 reference

16 August 2017

4

1 reference

16 August 2017

515-526

1 reference

New approaches and therapeutics targeting apoptosis in disease

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mitochondria: pharmacological manipulation of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Control of T cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Autoimmune disease: why and where it occurs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Cell death in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Ischemia/reperfusion injury at the intersection with cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Apoptosis in cerebral ischemia: executional and regulatory signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Targeting death receptors in cancer with Apo2L/TRAIL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Ways of dying: multiple pathways to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

AP-1 as a regulator of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

NF-kappaB at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Life in the balance: how BH3-only proteins induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Generation and characterization of Smac/DIABLO-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

IAPs, RINGs and ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mitochondrial membrane permeability transition and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mitochondrial free radical production and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Direct activation of the apoptosis machinery as a mechanism to target cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Apoptosome: a platform for the activation of initiator caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The mitochondrial death squad: hardened killers or innocent bystanders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Caspases: pharmacological manipulation of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Apoptosis in amyotrophic lateral sclerosis--what is the evidence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Caspase inhibitors promote alternative cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

First-in-class pan caspase inhibitor developed for the treatment of liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Oncogene-dependent apoptosis in extracts from drug-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Dr. Josef Steiner Cancer Research Prize Lecture: the role of physiological cell death in neoplastic transformation and in anti-cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

Caspase activation is not death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.4.515

10.1517/14728222.11.4.515

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17373881